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Submit ReviewTC-S 7001
说明： Potent and highly selective ROCK inhibitor; orally active
别名： Azaindole-1,BAY-549
化学名： 6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine
纯度： ≥98% (HPLC)
生物活性 for TC-S 7001
TC-S 7001 (also known as BAY-549) is a potent and highly selective ROCK inhibitor (IC50 values are 0.6 and 1.1 nM for human ROCK1 and ROCK2, respectively), which exhibits >200-fold selectivity over TRK and FLT3 receptors, and >900-fold selectivity over a panel of other kinases and cardiovascular relevent enzymes and receptors. TC-S 7001 reduces blood pressure in normotensive and hypertensive rats, and is orally active.
External Portal Information for TC-S 7001
Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of TC-S 7001 (BAY 549) is reviewed on chemicalprobes.org and the SGC website.
技术数据 for TC-S 7001
| 分子量 | 402.79 |
| 公式 | C18H13ClF2N6O |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 867017-68-3 |
| PubChem ID | 11524200 |
| InChI Key | NRSGWEVTVGZDFC-UHFFFAOYSA-N |
| Smiles | ClC1=CC(NC2=CC(F)=C(OC3=C(C(C)=CN4)C4=NC=C3)C(F)=C2)=NC(N)=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for TC-S 7001
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 40.28 | 100 | |
| ethanol | 40.28 | 100 |
制备储备液 for TC-S 7001
以下数据基于产品分子量 402.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.48 mL | 12.41 mL | 24.83 mL |
| 5 mM | 0.5 mL | 2.48 mL | 4.97 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.48 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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产品说明书 for TC-S 7001
参考文献 for TC-S 7001
参考文献是支持产品生物活性的出版物。
Kast et al (2007) Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase. Br.J.Pharmacol. 152 1070 PMID: 17934515
Dahal et al (2010) Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension. Eur.Resp.J. 36 808 PMID: 20530035
If you know of a relevant reference for TC-S 7001, please let us know.
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关键词: TC-S 7001, TC-S 7001 supplier, TC-S7001, Azaindole-1, potent, selective, rho-kinase, inhibitors, inhibits, ROCK1, ROCK2, BAY-549, Rho-kinases, 4961, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.