TC-S 7009

Pricing Availability   Qty
说明: High affinity and selective HIF-2α inhibitor
化学名: N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
纯度: ≥99% (HPLC)
说明书
引用文献 (2)
评论
文献 (2)

生物活性 for TC-S 7009

TC-S 7009 is a high affinity and selective HIF-2α inhibitor (Kd = 81 nM). Binds to the HIF-2α PAS-B domain; disrupts HIF-2α-ARNT heterodimerization. Exhibits >60-fold selectivity for HIF-2α over HIF-1α. Decreases HIF-2α DNA-binding and attenuates expression of HIF-2α target genes in vitro.

化合物库 for TC-S 7009

TC-S 7009 is also offered as part of the Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for TC-S 7009

分子量 308.65
公式 C12H6ClFN4O3
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 1422955-31-4
PubChem ID 70697712
InChI Key CDQUJZKBRAFWNG-UHFFFAOYSA-N
Smiles ClC1=CC(F)=CC(NC3=C([N+]([O-])=O)C2=NON=C2C=C3)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TC-S 7009

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.86 100

制备储备液 for TC-S 7009

以下数据基于产品分子量 308.65。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.2 mL 32.4 mL
5 mM 0.65 mL 3.24 mL 6.48 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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产品说明书 for TC-S 7009

分析证书/产品说明书
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参考文献 for TC-S 7009

参考文献是支持产品生物活性的出版物。

Scheuermann et al (2013) Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat.Chem.Biol. 9 271 PMID: 23434853

Rogers et al (2013) Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. J.Med.Chem. 56 1739 PMID: 23363003

Wu et al (2019) Bidirectional modulation of HIF-2 activity through chemical ligands. Nat.Chem.Biol. 15 367 PMID: 30804532


If you know of a relevant reference for TC-S 7009, please let us know.

按产品操作查看相关产品

查看全部 Hypoxia Inducible Factor (HIF) Inhibitors

关键词: TC-S 7009, TC-S 7009 supplier, TC-S7009, high, affinity, inhibits, inhibitors, HIF2α, HIF2a, HIF2alpha, PASB, hypoxia-inducible, factors, OX3, 0X3, Hypoxia, Inducible, Factors, 5243, Tocris Bioscience

2 篇 TC-S 7009 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TC-S 7009 的部分引用包括:

Sasagawa et al (2018) HIF-2α, but not HIF-1α, mediates hypoxia-induced up-regulation of Flt-1 gene expression in placental trophoblasts. Sci Rep 8 17375 PMID: 30478339

Kyoung Min et al (2020) A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression. Nat Commun 11 5023 PMID: 33024108


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