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TC-S 7010

Cat. No. 5286 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5286 has been discontinued.

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说明： Potent and selective Aurora kinase A inhibitor
化学名： N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-benzamide
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for TC-S 7010

TC-S 7010 is a potent and selective inhibitor of Aurora kinase A (IC50 = 3.4 nM); exhibits 1000-fold selectivity for Aurora kinase A over Aurora kinase B. Displays antiproliferative activity in HCT116 and HT29 cells (IC50 values are 0.19 and 2.9 μM respectively).

技术数据 for TC-S 7010

分子量 588.07
公式 C31H31ClFN7O2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1158838-45-9
PubChem ID 44139710
InChI Key AKSIZPIFQAYJGF-UHFFFAOYSA-N
Smiles O=C(NC3=CC=CC=C3Cl)C(C=C2)=CC=C2NC1=C(F)C=NC(NC4=CC=C(CC(N5CCN(CC)CC5)=O)C=C4)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for TC-S 7010

参考文献是支持产品生物活性的出版物。

Aliagas-Martin et al (2009) A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J.Med.Chem. 52 3300 PMID: 19402633

Yuan et al (2012) Overcoming CML acquired resistance by specific inhibition of Aurora A kinse in the KCL-22 cell model. Carcinogenesis 33 285 PMID: 22116466

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关键词: TC-S 7010, TC-S 7010 supplier, TC-S7010, Aurora, kinase, A, potent, selective, inhibitors, inhibits, antiproliferative, Kinases, 5286, Tocris Bioscience

1 篇 TC-S 7010 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TC-S 7010 的部分引用包括：

Alexandre et al (2020) KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling. J Cell Biol 219 PMID: 32348467

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