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Submit ReviewTC SL C5 is a metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor (KD = 2.9 μM). Binds Malat1 3' terminal stability element for nuclear expression (ENE) triplex. Reduces Malat1 RNA levels by 54% and branching morphogenesis by 38% in mammary tumor organoids. Modulates Malat1 downstream genes without affecting Neat1.
TC SL C5 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
分子量 | 323.4 |
公式 | C19H21N3O2 |
储存 | Store at -20°C |
纯度 | ≥98% (HPLC) |
CAS Number | 827327-28-6 |
PubChem ID | 1096509 |
InChI Key | LCVOJBGSGIOMKF-UHFFFAOYSA-N |
Smiles | COC1=CC=C(C=C1)C1=CN=C(NCC2=CC(OC)=CC=C2)N1C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 32.34 | 100 | |
ethanol | 32.34 | 100 |
以下数据基于产品分子量 323.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 3.09 mL | 15.46 mL | 30.92 mL |
5 mM | 0.62 mL | 3.09 mL | 6.18 mL |
10 mM | 0.31 mL | 1.55 mL | 3.09 mL |
50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
参考文献是支持产品生物活性的出版物。
Abulwerdi et al (2019) Selective small-molecule targeting of a triple helix encoded by the long noncoding RNA, MALAT1. ACS Chem.Biol. 14 223 PMID: 30620551
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关键词: TC SL C5, TC SL C5 supplier, TCSLC5, MALAT1, Metastasis-associated, lung, adenocarcinoma, transcript, 1, RNA, inhibitors, inhibits, breast, cancer, element, for, nuclear, expression, ENE, triplex, SM5, MALAT1IN1, MALAT1-IN-1, DNA,, and, Protein, Synthesis, 6884, Tocris Bioscience
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