TC SL C5

Pricing Availability   Qty
说明: Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor
别名: SM5,MALAT1-IN-1
化学名: 5-(4-Methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-1-methyl-1H-Imidazol-2-amine
纯度: ≥98% (HPLC)
说明书
引用文献
评论
文献 (2)

生物活性 for TC SL C5

TC SL C5 is a metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor (KD = 2.9 μM). Binds Malat1 3' terminal stability element for nuclear expression (ENE) triplex. Reduces Malat1 RNA levels by 54% and branching morphogenesis by 38% in mammary tumor organoids. Modulates Malat1 downstream genes without affecting Neat1.

化合物库 for TC SL C5

TC SL C5 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for TC SL C5

分子量 323.4
公式 C19H21N3O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 827327-28-6
PubChem ID 1096509
InChI Key LCVOJBGSGIOMKF-UHFFFAOYSA-N
Smiles COC1=CC=C(C=C1)C1=CN=C(NCC2=CC(OC)=CC=C2)N1C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TC SL C5

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.34 100
ethanol 32.34 100

制备储备液 for TC SL C5

以下数据基于产品分子量 323.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.09 mL 15.46 mL 30.92 mL
5 mM 0.62 mL 3.09 mL 6.18 mL
10 mM 0.31 mL 1.55 mL 3.09 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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参考文献 for TC SL C5

参考文献是支持产品生物活性的出版物。

Abulwerdi et al (2019) Selective small-molecule targeting of a triple helix encoded by the long noncoding RNA, MALAT1. ACS Chem.Biol. 14 223 PMID: 30620551


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关键词: TC SL C5, TC SL C5 supplier, TCSLC5, MALAT1, Metastasis-associated, lung, adenocarcinoma, transcript, 1, RNA, inhibitors, inhibits, breast, cancer, element, for, nuclear, expression, ENE, triplex, SM5, MALAT1IN1, MALAT1-IN-1, DNA,, and, Protein, Synthesis, 6884, Tocris Bioscience

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