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Submit ReviewTCS 183
说明： Fragment 1-13 of GSK-3β sequence
生物活性 for TCS 183
TCS 183 is a fragment 1-13 of human and mouse GSK-3β sequence. Potentially useful as a competitive inhibitor of GSK-3β (Ser9) phosphorylation.
Control Peptide also available.
技术数据 for TCS 183
| 分子量 | 1425.58 |
| 公式 | C58H96N20O20S |
| 序列 |
MSGRPRTTSFAES (Modifications: Ser-13 = C-terminal amide) |
| 储存 | Desiccate at -20°C |
| PubChem ID | 90488752 |
| InChI Key | CPHAYBWPVDHKAJ-BOGMMOMNSA-N |
| Smiles | [H]N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TCS 183
参考文献 for TCS 183
参考文献是支持产品生物活性的出版物。
Peineau et al (2007) GSK3β mediates a novel interaction between LTP and LTD in the hippocampus. Neuron 53 703 PMID: 17329210
关键词: TCS 183, TCS 183 supplier, Fragment, 1-13, GSK-3β, GSK-3beta, sequence, Glycogen, Synthase, Kinases, 3, Carbohydrate, Metabolism, TCS183, Kinase, 2236, Tocris Bioscience
2 篇 TCS 183 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TCS 183 的部分引用包括：
Vargas et al (2014) In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer's disease model. J Neurosci 34 2191 PMID: 24501359
Peineau et al (2007) LTP inhibits LTD in the hippocampus via regulation of GSK3beta. Neuron 53 703 PMID: 17329210
TCS 183 的评论
平均评分: 5 (Based on 1 Review.)
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TCS-183 efficiently blocks Wnt/ beta-catenin pathway in vivo.
By
Jessica Vargas on 01/06/2018
分析类型： In Vivo
种属： Mouse
细胞系/组织： Brain
TCS-183, a competitive inhibitor of the inactivating GSK-3 beta phosphorylation, was used to block the activation of Wnt/ beta-catenin pathway in vivo. 300 micro-Molar of TCS-183 was diluted in sterile artificial cerebrospinal fluid and 0.01% DMSO. Chronic intracerebral delivery of the product was achieved via an osmotic mini-pump implanted on C57BL/6 mice.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Pathways for TCS 183
