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Submit ReviewTCS 2312
说明： Potent Chk1 inhibitor
化学名： 4'-[5-[[3-[(Cyclopropylamino)methyl]phenyl]amino]-1H-pyrazol-3-yl]-[1,1'-biphenyl]-2,4-diol
纯度： ≥97% (HPLC)
生物活性 for TCS 2312
TCS 2312 is a potent and selective checkpoint kinase 1 (chk1) inhibitor (Ki = 0.38 nM, EC50 = 60 nM). Enhances the cell killing activity of Gemcitabine (Cat. No. 3259) in breast and prostate cancer cell lines and displays antiproliferative effects in vitro.
技术数据 for TCS 2312
| 分子量 | 412.48 |
| 公式 | C25H24N4O2 |
| 储存 | Store at -80°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 838823-31-7 |
| PubChem ID | 11258443 |
| InChI Key | BYFCMDWKTJJQGR-UHFFFAOYSA-N |
| Smiles | OC1=CC(O)=CC=C1C2=CC=C(C3=CC(NC4=CC=C(CNC5CC5)C=C4)=NN3)C=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TCS 2312
参考文献 for TCS 2312
参考文献是支持产品生物活性的出版物。
Teng et al (2007) Structure-based design of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors. J.Med.Chem. 50 5253 PMID: 17887663
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关键词: TCS 2312, TCS 2312 supplier, Potent, Chk1, inhibitors, inhibits, Checkpoint, Kinases, Control, TCS2312, 3038, Tocris Bioscience
2 篇 TCS 2312 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TCS 2312 的部分引用包括：
Davari et al (2014) Checkpoint kinase 2 is required for efficient immunoglobulin diversification. Cell Cycle 13 3659 PMID: 25483076
Frankenberger et al (2014) Checkpoint kinase 1 negatively regulates somatic hypermutation. Nucleic Acids Res 42 3666 PMID: 24423870
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.