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TCS PIM-1 4a

Cat. No. 3714 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3714 has been discontinued.

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说明： Selective, ATP-competitive Pim kinase inhibitor
别名： SMI-4a
化学名： (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
纯度： ≥98% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for TCS PIM-1 4a

Selective, ATP-competitive Pim kinase inhibitor (IC50 values are 24 and 100 nM for Pim-1 and Pim-2 respectively). Displays selectivity over a panel of ~50 other kinases tested. Exhibits cytotoxicity in PC3 prostate carcinoma cells in vitro (IC50 = 17 μM).

技术数据 for TCS PIM-1 4a

分子量 273.23
公式 C11H6F3NO2S
储存 Desiccate at +4°C
纯度 ≥98% (HPLC)
CAS Number 438190-29-5
PubChem ID 1361334
InChI Key NGJLOFCOEOHFKQ-YVMONPNESA-N
Smiles O=C(/C(S2)=C/C1=CC(C(F)(F)F)=CC=C1)NC2=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for TCS PIM-1 4a

参考文献是支持产品生物活性的出版物。

Xia et al (2009) Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J.Med.Chem. 52 74 PMID: 19072652

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关键词: TCS PIM-1 4a, TCS PIM-1 4a supplier, TCSPIM14a, pim-1, pim-2, kinases, inhibitors, inhibits, selective, ATP-competitive, SMI-4a, Pim, Kinase, 3714, Tocris Bioscience

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