TDZD 8

Cat. No. 6092 1 次引用 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective non-ATP competitive inhibitor of GSK 3β

别名： NP 01139

化学名： 2-Methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione

纯度： ≥98% (HPLC)

说明书

引用文献 (1)

文献 (4)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TDZD 8

TDZD 8 is a selective non-ATP competitive inhibitor of GSK 3β (IC₅₀ = 2 μM); thiadiazolidinone deriviative. Does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. Reduces severity of L-dopa-induced dyskinesia in a Parkinson's disease in vivo model.

技术数据 for TDZD 8

分子量	222.26
公式	C₁₀H₁₀N₂O₂S
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	327036-89-5
PubChem ID	4124851
InChI Key	JDSJDASOXWCHPN-UHFFFAOYSA-N
Smiles	CN1SC(N(C1=O)CC2=CC=CC=C2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TDZD 8

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	22.23	100
	ethanol	22.23	100

制备储备液 for TDZD 8

以下数据基于产品分子量 222.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	4.5 mL	22.5 mL	44.99 mL
5 mM	0.9 mL	4.5 mL	9 mL
10 mM	0.45 mL	2.25 mL	4.5 mL
50 mM	0.09 mL	0.45 mL	0.9 mL

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产品说明书 for TDZD 8

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TDZD 8

参考文献是支持产品生物活性的出版物。

Xie et al (2016) Inhibition of Glycogen Synthase Kinase-3β (GSK-3 beta ) as potent therapeutic strategy to ameliorates L-dopa-induced dyskinesia in 6-OHDA parkinsonian rats. Sci.Rep. 6 23527 PMID: 26997328

Martinez et al (2002) First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. J.Med.Chem. 45 1292 PMID: 11881998

If you know of a relevant reference for TDZD 8, please let us know.

按标靶查看相关产品

关键词: TDZD 8, TDZD 8 supplier, TDZD8, NP01139, NP_01139, Selective, non-ATP, competitive, inhibitor, GSK, 3, β, L-dopa-induced, dyskinesia, NP, 01139, Glycogen, Synthase, Kinase, 6092, Tocris Bioscience

1 篇 TDZD 8 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TDZD 8 的部分引用包括：

Coleen M et al (2020) Glycogen synthase kinase-3 inhibition rescues sex-dependent contextual fear memory deficit in human immunodeficiency virus-1 transgenic mice. Br J Pharmacol 177 5658-5676 PMID: 33080056

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TDZD 8 的评论

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Great GSK3 inhibitor.

By Anonymous on 11/25/2021

分析类型： In Vivo

种属： Mouse

细胞系/组织： Brain

I have used TDZD to inhibit GSK3 in the brain of mice. After the treatment, we investigated if the NCS-1 gene would increase its expression as we have hypothesised the GSK3 protein impairs NCS-1 gene expression. We found that this happened, but only in the pre frontal cortex (PFC) as showed by the figure.

We treated mice with TDZD-8 at 30 mg/kg, i.p. for 1 h

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Pathways for TDZD 8

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