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Submit ReviewTemsirolimus
说明： mTOR inhibitor; antitumor
别名： CCI-779
化学名： Rapamycin 42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate]
纯度： ≥98% (HPLC)
生物活性 for Temsirolimus
Temsirolimus is a mTOR inhibitor; inhibits tumor growth in breast cancer cell lines (IC50 values are 1.6 and 4.3 nM for SKBr3 and BT474, respectively). Inhibits HIF-1α-mediated VEGF production in breast cancer cell lines (BT474 and MDA-MB-231). Directly inhibits serum and VEGF mediated endothelial cell proliferation and morphogenesis in vitro and vessel formation in vivo. Causes G1/S cell cycle arrest in multiple cancer cell lines. Antiangiogenic. Activates autophagy.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for Temsirolimus
| 分子量 | 1030.29 |
| 公式 | C56H87NO16 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 162635-04-3 |
| PubChem ID | 6918289 |
| InChI Key | CBPNZQVSJQDFBE-FUXHJELOSA-N |
| Smiles | O=C([C@H](C)\C=C([C@@H](O)[C@@H](OC)C([C@@H]4C)=O)/C)C[C@]([C@H](C)C[C@H]2C[C@@H](OC)[C@H](OC(C(CO)(C)CO)=O)CC2)([H])OC([C@@]1([H])N(C(C([C@@]3(O)[C@H](C)CC[C@](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C4)C)OC)([H])O3)=O)=O)CCCC1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Temsirolimus
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 103.03 | 100 | |
| ethanol | 103.03 | 100 |
制备储备液 for Temsirolimus
以下数据基于产品分子量 1030.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.97 mL | 4.85 mL | 9.71 mL |
| 5 mM | 0.19 mL | 0.97 mL | 1.94 mL |
| 10 mM | 0.1 mL | 0.49 mL | 0.97 mL |
| 50 mM | 0.02 mL | 0.1 mL | 0.19 mL |
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产品说明书 for Temsirolimus
参考文献 for Temsirolimus
参考文献是支持产品生物活性的出版物。
Wang et al (2012) Inhibition of mammalian target of rapamycin signaling by CCI-779 (temsirolimus) induces growth inhibition and cell cycle arrest in Cashmere goat fetal fibroblasts (Capra hircus). DNA Cell Biol. 31 1095 PMID: 22320865
Del Bufalo et al (2006) Antiangiogenic potential of the Mammalian target of rapamycin inhibitor temsiro. Cancer Res. 66 5549 PMID: 16740688
Wu L et al (2005) Effects of the mammalian target of rapamycin inhibitor CCI-779 used alone or with chemotherapy on human prostate cancer cells and xenografts. Cancer Res. 65 2825 PMID: 15805283
Li et al (2013) The novel mTOR inhibitor CCI-779 (temsirolimus) induces antiproliferative effects through inhibition of mTOR in Bel-7402 liver cancer cells. Cancer Cell Int. 13 PMID: 23537100
Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316
If you know of a relevant reference for Temsirolimus, please let us know.
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关键词: Temsirolimus, Temsirolimus supplier, Breast, cancer, mTOR, inhibitors, inhibits, rapamycin, kinases, suppresses, cell, tumour, tumor, growth, VEGF, Vascular, endothelial, factor, CCI-779, Cell, Cycle, Inhibitors, Autophagy, 5264, Tocris Bioscience
3 篇 Temsirolimus 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Temsirolimus 的部分引用包括：
Jun et al (2021) RNA N6-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m6A-GLUT1-mTORC1 Axis and Is a Therapeutic Target. Gastroenterology 160 1284-1300.e16 PMID: 33217448
Liu (2018) In vivo brain GPCR signaling elucidated by phosphoproteomics. Science 360 eaao4927 PMID: 29930108
Olmez et al (2017) Combined CDK4/6 and mTOR Inhibition Is Synergistic against Glioblastoma via Multiple Mechanisms. Clin Cancer Res 23 6958 PMID: 28814434
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Temsirolimus 的评论
平均评分: 5 (Based on 1 Review.)
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Temsirolimus abolishes aversion induced by kappa opioid receptor agonists.
By
Luca Zangrandi on 08/13/2021
分析类型： In Vivo
种属： Mouse
Conditioned place aversion. Systemic administration
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cancer Metabolism Research Product Guide
This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:
- Glycolysis
- Tricarboxylic Acid Cycle
- Lipidogenesis
- 1C Metabolism and Nucleic Acid Synthesis
- Drivers of Metabolic Reprogramming
- pH and Redox Balance
Cancer Metabolism Poster
This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.
Pathways for Temsirolimus
