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Submit ReviewThiostrepton
说明： Antibiotic, inhibits protein synthesis
纯度： ≥90% (HPLC)
生物活性 for Thiostrepton
Thiostrepton is an antibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.
技术数据 for Thiostrepton
| 分子量 | 1664.89 |
| 公式 | C72H85N19O18S5 |
| 储存 | Store at -20°C |
| 纯度 | ≥90% (HPLC) |
| CAS Number | 1393-48-2 |
| PubChem ID | 16129666 |
| InChI Key | NSFFHOGKXHRQEW-DVRIZHICSA-N |
| Smiles | C=C(C(NC(C(N)=O)=C)=O)NC(C1=CSC(C2=NC(C3=CSC(C(C(C)OC(C4=CC(C(C)O)=C(C=CC(NC(C(NC(C)C(NC(C(NC(C)C5=O)=O)=C)=O)=O)C(C)CC)C6O)C6=N4)=O)N7)=N3)C(CC2)(N5)C8=NC(C(NC(C(N/C(C9=NC(C(NC(C(O)(C)C(C)O)C%10=NC(C7=O)=CS%10)=O)CS9)=C/C)=O)C(O)C)=O)=CS8)=N1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Thiostrepton
参考文献 for Thiostrepton
参考文献是支持产品生物活性的出版物。
Ruben et al (2007) Thiostrepton inhibition of tRNA delivery to the ribosome. RNA 13 2091 PMID: 17951333
Kwok et al (2008) Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression. Mol.Cancer Ther. 7 2022 PMID: 18645012
Rodnina et al (1999) Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome. Proc.Natl.Acad.Sci.USA 96 9586
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关键词: Thiostrepton, Thiostrepton supplier, Downregulates, FOXM1, Antibiotics, inhibits, inhibitors, Hh, Signaling, Signalling, Hedgehog, Transcription, Factors, protein, synthesis, DNA,, RNA, and, Protein, Synthesis, Other, 3267, Tocris Bioscience
3 篇 Thiostrepton 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Thiostrepton 的部分引用包括：
Uddin et al (2011) Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy. Am J Pathol 178 537 PMID: 21281787
Lin et al (2013) Inhibition of FOXM1 by thiostrepton sensitizes medulloblastoma to the effects of chemotherapy. Oncol Rep 30 1739 PMID: 23912794
Huang et al (2019) FoxM1 Induced PTX Resistance via Activation of the FoxM1/PHB1/RAF-MEK-ERK Pathway and Enhancement of the ABCA2 Transporter. Mol Ther Oncolytics 14 196 PMID: 31334335
Thiostrepton 的评论
平均评分: 5 (Based on 1 Review.)
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Thiostrepton was used to treat acquired cisplatin resistance.
By
Anonymous on 02/27/2019
分析类型： In Vitro
种属： Human
Thiostrepton was used to treat acquired cisplatin resistance in breast cancer cells under in in vitro conditions.
Insoluble in the lower alcohols, nonpolar organic solvents, diluted aqueous acids or bases
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Huntington's Disease Research Product Guide
This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:
- Somatic Instability
- Proteolysis and Inclusion Bodies
- Transcriptional Dysregulation
- Mitochondrial Dysfunction
- Nuclear-Cytoplasmic Transport Interference
- Excitotoxicity
- Stem Cells