TM 5441

Cat. No. 6194 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Plasminogen activator inhibitor-1 (PAI-1) inhibitor

化学名： 5-Chloro-2-[[2-[2-[[3-(3-furanyl)phenyl]amino]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TM 5441

TM 5441 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor (IC₅₀ = 3.58 - 60.3 μM). Increases apoptosis in human cancer cell lines. Reduces senescence and increases lifespan in mouse models of ageing (kl/kl). Inhibits L-NAME (Cat.No. 0665) induced systolic blood pressure increases, telomere length reduction and cardiac hypertrophy in mice. Renoprotective. Orally bioavailable.

化合物库 for TM 5441

TM 5441 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for TM 5441

分子量	450.8
公式	C₂₁H₁₆ClN₂NaO₆
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	2319722-53-5
PubChem ID	44250349
InChI Key	RDKPAESSEMYFJL-UHFFFAOYSA-M
Smiles	O=C(C1=C(C=CC(Cl)=C1)NC(COCC(NC2=CC=CC(C3=COC=C3)=C2)=O)=O)O[Na]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TM 5441

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	45.08	100

制备储备液 for TM 5441

以下数据基于产品分子量 450.8。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.22 mL	11.09 mL	22.18 mL
5 mM	0.44 mL	2.22 mL	4.44 mL
10 mM	0.22 mL	1.11 mL	2.22 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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产品说明书 for TM 5441

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TM 5441

参考文献是支持产品生物活性的出版物。

Placencio et al (2015) Small molecule inhibitors of plasminogen activator inhibitor-1 elicit anti-tumorigenic and anti-angiogenic activity. PLoS One. 10 PMID: 26207899

Jeong et al (2016) Novel plasminogen activator inhibitor-1 inhibitors prevent diabetic kidney injury in a mouse model. PLoS One. 11 PMID: 27258009

Boe et al (2013) Plasminogen activator inhibitor-1 antagonist TM5441 attenuates N^ω-nitro-L-arginine methyl ester-induced hypertension and vascular senescence. Circulation. 128 2318 PMID: 24092817

Eren et al (2014) PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. Proc.Natl.Acad.Sci.USA. 111 7090 PMID: 24778222

If you know of a relevant reference for TM 5441, please let us know.

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关键词: TM 5441, TM 5441 supplier, TM5441, PAI-1, inhibitor, inhibits, cancer, apoptosis, senescence, ageing, blood, pressure, telomere, hypertrophy, renoprotective, orally, bioavailable, Plasminogen, Activator, Inhibitor, 1, 6194, Tocris Bioscience

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