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Submit ReviewTocrisolve™ 100
说明： Water-soluble emulsion; negative control for reagents in TocrisolveTM 100
生物活性 for Tocrisolve™ 100
Water soluble emulsion composed of a 1:4 ratio of soya oil/water that is emulsified with the block co-polymer Pluronic F68. Can be diluted with any aqueous medium. Used to solubilize hydrophobic organic chemicals and water-insoluble lipids such as cannabinoids and vanilloids. The cannabinoid or vanilloid is incorporated with the emulsion as part of a specialized innovative production process. The soya oil forms a coating around the cannabinoid molecule, and the block co-polymer is added to stabilize the emulsion, preventing the lipid droplets from coalescing (merging) in the surrounding water. Also can be used as a negative control for reagents in TocrisolveTM 100; Anandamide, AM 404, VDM 11, ACPA, (R)-(+)-Methanandamide, JWH 133 and Arachidonic acid (Cat. Nos. 1017, 1685, 1686, 1781, 1782, 1783 and 2756 respectively).
技术数据 for Tocrisolve™ 100
| 储存 | Store at +4°C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Tocrisolve™ 100
参考文献 for Tocrisolve™ 100
参考文献是支持产品生物活性的出版物。
Hosseini et al (2006) Chronic topical administration of WIN-55-212-2 maintains a reduction in IOP in a rat glaucoma model without adverse effects. Exp.Eye Res. 82 753 PMID: 16289049
Oltmanns et al (2008) Topical WIN55212-2 alleviates intraocular hypertenision in rats through a CB1 receptor mediated mechanism of action. J.Ocul.Pharmacol.Ther. 24 104 PMID: 18201139
关键词: Tocrisolve 100, Tocrisolve 100 supplier, Water-soluble, emulsion, negative, control, 7, 1685, 1686, 1781, 1782, 1783, 2756, Tocrisolve100, Other, Cannabinoids, TRPV, 1684, Tocris Bioscience
25 篇 Tocrisolve™ 100 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Tocrisolve™ 100 的部分引用包括：
Diniz et al (2019) Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors. PeerJ 7 e6493 PMID: 30809460
Hwang et al (2015) Enhanced Production of Adenosine Triphosphate by Pharmacological Activation of Adenosine Monophosphate-Activated Protein Kinase Ameliorates Acetaminophen-Induced Liver Injury. J Neuroinflammation 38 843 PMID: 26434492
Nishikawa et al (2015) Cytoprotective Effects of Lysophospholipids from Sea Cucumber Holothuria atra. Br J Pharmacol 10 e0135701 PMID: 26275144
Wyeth et al (2010) Selective reduction of cholecystokinin-positive basket cell innervation in a model of temporal lobe epilepsy. J Neurosci 30 8993 PMID: 20592220
Zhang et al (2010) Cannabinoid CB1 receptor facilitation of substance P release in the rat spinal cord, measured as neurokinin 1 receptor internalization. Eur J Neurosci 31 225 PMID: 20074214
Ho et al (2010) Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex. Br J Pharmacol 160 736 PMID: 20590576
Chen et al (2016) Spatial Distribution of the Cannabinoid Type 1 and Capsaicin Receptors May Contribute to the Complexity of Their Crosstalk. Sci Rep 6 33307 PMID: 27653550
Montecucco et al (2012) The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques. Br J Pharmacol 33 846 PMID: 22112961
Medina-Rodríguez et al (2017) Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis. Sci Rep 7 43545 PMID: 28256546
Toguri et al (2014) Anti-inflammatory effects of cannabinoid CB(2) receptor activation in endotoxin-induced uveitis. Behav Brain Res 171 1448 PMID: 24308861
Amenta et al (2014) Cannabinoid receptor type-2 stimulation, blockade, and deletion alters the vascular inflammatory responses to traumatic brain injury. PLoS One 11 191 PMID: 25416141
Fraga-Silva et al (2013) Treatment with CB2 agonist JWH-133 reduces histological features associated with erectile dysfunction in hypercholesterolemic mice. Clin Dev Immunol 2013 263846 PMID: 24302957
Li et al (2013) Electroacupuncture modulation of reflex hypertension in rats: role of cholecystokinin octapeptide. Am J Physiol Regul Integr Comp Physiol 305 R404 PMID: 23785073
Redondo et al (2012) Identification in silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice. ACS Chem Neurosci 3 793 PMID: 23077723
Tjen-A-Looi et al (2009) Processing cardiovascular information in the vlPAG during electroacupuncture in rats: roles of endocannabinoids and GABA. J Appl Physiol (1985) 106 1793 PMID: 19325030
Brozoski et al (2009) Differential endocannabinoid regulation of baroreflex-evoked sympathoinhibition in normotensive versus hypertensive rats. Auton Neurosci 150 82 PMID: 19464961
Mendiguren and Pineda (2009) Effect of the CB(1) receptor antagonists rimon. and AM251 on the firing rate of dorsal raphe nucleus neurons in rat brain slices. Br J Pharmacol 158 1579 PMID: 19845674
Boychuk et al (2013) Rapid Glucocorticoid-Induced Activation of TRP and CB1 Receptors Causes Biphasic Modulation of Glutamate Release in Gastric-Related Hypothalamic Preautonomic Neurons. Front Neurosci 7 3 PMID: 23386808
Li et al (2013) Inhibition of p38/Mk2 signaling pathway improves the anti-inflammatory effect of WIN55 on mouse experimental colitis. Lab Invest 93 322 PMID: 23381627
Enman and Unterwald (2012) Inhibition of GSK3 attenuates amphetamine-induced hyperactivity and sensitization in the mouse. J Neurosci 231 217 PMID: 22649795
Hilgers et al (2010) Twenty-four-hour exposure to altered blood flow modifies endothelial Ca2+-activated K+ channels in rat mesenteric arteries. J Pharmacol Exp Ther 333 210 PMID: 20040579
Lamy et al (2010) Allosteric block of KCa2 channels by apamin. J Biol Chem 285 27067 PMID: 20562108
Akerman et al (2007) Cannabinoid (CB1) receptor activation inhibits trigeminovascular neurons. J Pharmacol Exp Ther 320 64 PMID: 17018694
Esposito et al (2007) Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression. Br J Pharmacol 151 1272 PMID: 17592514
Gaskari et al (2005) Role of endocannabinoids in the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats. Eur Heart J 146 315 PMID: 16025138
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.