TPPB

Cat. No. 5343 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： High affinity PKC activator; also APP modulator

化学名： (2E,4E)-N-[(2S,5S)-1,2,3,4,5,6-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3-oxo-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienamide

纯度： ≥98% (HPLC)

说明书

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TPPB

TPPB is a high affinity and cell permeable protein kinase C activator (K_i =11.9 nM), which induces differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells. TPPB also enhances the non-amyloidgenic processing of amyloid precursor protein, increasing secretion of sAPPα.

技术数据 for TPPB

分子量	501.54
公式	C₂₇H₃₀F₃N₃O₃
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	497259-23-1
PubChem ID	9935767
InChI Key	WOLVEMPZUIFSII-IHHOKICGSA-N
Smiles	CC([C@@H]1N(C2=CC=C(C=C2C[C@H](NC1=O)CO)NC(/C=C/C=C/C3=CC=C(C(F)(F)F)C=C3)=O)C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TPPB

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	25.08	50

制备储备液 for TPPB

以下数据基于产品分子量 501.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	3.99 mL	19.94 mL	39.88 mL
2.5 mM	0.8 mL	3.99 mL	7.98 mL
5 mM	0.4 mL	1.99 mL	3.99 mL
25 mM	0.08 mL	0.4 mL	0.8 mL

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产品说明书 for TPPB

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TPPB

参考文献是支持产品生物活性的出版物。

Rezania et al (2014) Reversal of diabetes with Ins-producing cells derived in vitro from human pluripotent stem cells. Nat.Biotechnol. 32 1121 PMID: 25211370

Chen et al (2009) A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat.Chem.Biol. 5 258 PMID: 19287398

Kozikowski et al (2003) New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPα. J.Med.Chem. 46 364 PMID: 12540236

If you know of a relevant reference for TPPB, please let us know.

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