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UC 112

Cat. No. 5251 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5251 has been discontinued.

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说明： IAP and XIAP inhibitor; antitumor
化学名： 5-[(Phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for UC 112

UC 112 is an iAP inhibitor (IC50 values from 0.7 - 3.4 μM); inhibits cell growth in multiple cancer cell lines and in a melanoma xenograft model in vivo. Also suppresses X-linked inhibitor of apoptosis protein (XIAP) and survivin levels. Inhibits the growth of P-glycoproteins and activates caspase-3/7 and caspase-9.

技术数据 for UC 112

分子量 348.44
公式 C22H24N2O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 383392-66-3
PubChem ID 3426979
InChI Key LTGLGIQQZXSLLF-UHFFFAOYSA-N
Smiles OC1=C3C(C=CC=N3)=C(COCC4=CC=CC=C4)C=C1CN2CCCC2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for UC 112

参考文献是支持产品生物活性的出版物。

Wang Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors. J.Pharmacol.Exp.Ther. 349 319 PMID: 24623800

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关键词: UC 112, UC 112 supplier, UC112, inhibitors, inhibits, apoptosis, proteins, antitumor, multidrug, resistant, caspase, Inhibitor, of, Apoptosis, (IAP), 5251, Tocris Bioscience

1 篇 UC 112 的引用文献

引用文献是使用了 Tocris 产品的出版物。 UC 112 的部分引用包括：

Schwalm et al (2022) A toolbox for the generation of chemical probes for baculovirus IAP repeat containing proteins Front.Cell.Dev.Biol. 10 886537 PMID: 35721509

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Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for UC 112

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.