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VE 821

Cat. No. 6160 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6160 has been discontinued.

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说明： High affinity and selective ATP-competitive ATR inhibitor
化学名： 3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for VE 821

VE 821 is a high affinity and selective ATP-competitive ATR inhibitor (Ki = 13 nM). Exhibits >75-fold selectivity for ATR over related kinases mTOR, DNA-PK, PI 3-Kγ and PIKKs (Ki values are >1, 2.2, 3.9 and 16 μM, respectively) and a panel of other kinases. Induces cell death in colon cancer cell lines in vitro and sensitizes tumor cells to treatment with DNA damaging anticancer agents.

技术数据 for VE 821

分子量 368.41
公式 C18H16N4O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1232410-49-9
PubChem ID 51000408
InChI Key DUIHHZKTCSNTGM-UHFFFAOYSA-N
Smiles CS(=O)(C1=CC=C(C2=NC(C(NC3=CC=CC=C3)=O)=C(N=C2)N)C=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for VE 821

参考文献是支持产品生物活性的出版物。

Reaper et al (2011) Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. Nat.Chem.Biol. 7 428 PMID: 21490603

Williamson et al (2016) ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A. Nat.Commun. 7 13837 PMID: 27958275

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关键词: VE 821, VE 821 supplier, VE821, ATR, Ataxia, telangiectasia, and, Rad3, related, kinases, inhibitors, inhibits, high, affinity, selective, sensitizes, sensitizing, DNA, damage, damaging, ATM, &, Kinase, 6160, Tocris Bioscience

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