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Viomycin

Cat. No. 3787 5 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Antibiotic; inhibits bacterial DNA synthesis
化学名： (S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4-hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamide disulfate
说明书
引用文献 (5)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Viomycin

Viomycin is a member of the tuberactinomycin family of antibiotics. Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans-cleavage of the Neurospora VS ribozyme.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

技术数据 for Viomycin

分子量 881.85
公式 C25H43N13O10.2H2SO4
储存 Store at -20°C
PubChem ID 90488875
InChI Key HMKHTQGEDRQEOM-IGZVKJTASA-N
Smiles O[C@H](N1)C[C@@H]([C@H](C(NC[C@@H](C(N[C@@H](CO)C(N[C@H](C(N2)=O)CO)=O)=O)NC(C[C@@H](N)CCCN)=O)=O)NC(/C2=C/NC(N)=O)=O)NC1=N.OS(O)(=O)=O.OS(O)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Viomycin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 66.14 75

制备储备液 for Viomycin

以下数据基于产品分子量 881.85。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.75 mM 1.51 mL 7.56 mL 15.12 mL
3.75 mM 0.3 mL 1.51 mL 3.02 mL
7.5 mM 0.15 mL 0.76 mL 1.51 mL
37.5 mM 0.03 mL 0.15 mL 0.3 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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参考文献 for Viomycin

参考文献是支持产品生物活性的出版物。

Ermolenko et al (2007) The antibiotic vio. traps the ribosome in an intermediate state of translocation. Nat.Struct.Mol.Biol. 14 493 PMID: 17515906

Hausner et al (1988) The allosteric three-site model for the ribosomal elongation cycle. J.Biol.Chem. 263 13103 PMID: 2843509

Schroeder et al (2000) Modulation of RNA function by aminoglycoside antibiotics. EMBO J. 19 1 PMID: 10619838

If you know of a relevant reference for Viomycin, please let us know.

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关键词: Viomycin, Viomycin supplier, Viomycin, disulfate, Pfizer, antibiotics, inhibits, inhibitors, bacterial, DNA, synthesis, 37883-00-4, DNA,, RNA, and, Protein, Synthesis, Antibiotics, 3787, Tocris Bioscience

5 篇 Viomycin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Viomycin 的部分引用包括：

Samokhvalov et al (2015) PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. PLoS One 232 44105 PMID: 25300478

Abad et al (2018) Common metabolic pathways implicated in resistance to chemotherapy point to a key mitochondrial role in breast cancer. Mol Cell Proteomics PMID: 30373788

Akbergenov et al (2011) Molecular basis for the selectivity of antituberculosis compounds capreo. and vio. Antimicrob Agents Chemother 55 4712 PMID: 21768509

Matilde E et al (2019) Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer. Mol Cell Proteomics 18 231-244 PMID: 33451433

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Viomycin 的评论

平均评分: 4 (Based on 1 Review.)

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Viomycin and streptomycin were compared in inhibition of bacterial protein production.
By Anonymous on 02/13/2019
种属： Human

Viomycin and streptomycin were compared in inhibition of bacterial protein production.Cross-resistance between streptomycin and other aminoglycosides and polypeptides observed.

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