主页 / 细胞生物学 / Cell Metabolism / DNA, RNA and Protein Synthesis / DNA, RNA and Protein Synthesis Inhibitors / Viomycin

Viomycin

Cat. No. 3787 5 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Antibiotic; inhibits bacterial DNA synthesis
化学名： (S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4-hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamide disulfate
说明书
引用文献 (5)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Viomycin

Viomycin is a member of the tuberactinomycin family of antibiotics. Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans-cleavage of the Neurospora VS ribozyme.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

技术数据 for Viomycin

分子量 881.85
公式 C25H43N13O10.2H2SO4
储存 Store at -20°C
PubChem ID 90488875
InChI Key HMKHTQGEDRQEOM-IGZVKJTASA-N
Smiles O[C@H](N1)C[C@@H]([C@H](C(NC[C@@H](C(N[C@@H](CO)C(N[C@H](C(N2)=O)CO)=O)=O)NC(C[C@@H](N)CCCN)=O)=O)NC(/C2=C/NC(N)=O)=O)NC1=N.OS(O)(=O)=O.OS(O)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Viomycin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 66.14 75

制备储备液 for Viomycin

以下数据基于产品分子量 881.85。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.75 mM 1.51 mL 7.56 mL 15.12 mL
3.75 mM 0.3 mL 1.51 mL 3.02 mL
7.5 mM 0.15 mL 0.76 mL 1.51 mL
37.5 mM 0.03 mL 0.15 mL 0.3 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for Viomycin

参考文献是支持产品生物活性的出版物。

Ermolenko et al (2007) The antibiotic vio. traps the ribosome in an intermediate state of translocation. Nat.Struct.Mol.Biol. 14 493 PMID: 17515906

Hausner et al (1988) The allosteric three-site model for the ribosomal elongation cycle. J.Biol.Chem. 263 13103 PMID: 2843509

Schroeder et al (2000) Modulation of RNA function by aminoglycoside antibiotics. EMBO J. 19 1 PMID: 10619838

If you know of a relevant reference for Viomycin, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 DNA, RNA and Protein Synthesis Inhibitors

关键词: Viomycin, Viomycin supplier, Viomycin, disulfate, Pfizer, antibiotics, inhibits, inhibitors, bacterial, DNA, synthesis, 37883-00-4, DNA,, RNA, and, Protein, Synthesis, Antibiotics, 3787, Tocris Bioscience

5 篇 Viomycin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Viomycin 的部分引用包括：

Abad et al (2018) Common metabolic pathways implicated in resistance to chemotherapy point to a key mitochondrial role in breast cancer. Mol Cell Proteomics PMID: 30373788

Akbergenov et al (2011) Molecular basis for the selectivity of antituberculosis compounds capreo. and vio. Antimicrob Agents Chemother 55 4712 PMID: 21768509

Matilde E et al (2019) Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer. Mol Cell Proteomics 18 231-244 PMID: 33451433

Freihofer et al (2016) Nonmutational compensation of the fitness cost of antibiotic resistance in mycobacteria by overexpression of tlyA rRNA methylase. RNA 22 1836 PMID: 27698071

Samokhvalov et al (2015) PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. PLoS One 232 44105 PMID: 25300478

您是否知道使用了 Tocris Viomycin 的优秀论文？ 请告知我们.

Viomycin 的评论

平均评分: 4 (Based on 1 Review.)

5 星
0%
4 星
100%
3 星
0%
2 星
0%
1 星
0%

Have you used Viomycin?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Viomycin and streptomycin were compared in inhibition of bacterial protein production.
By Anonymous on 02/13/2019
种属： Human

Viomycin and streptomycin were compared in inhibition of bacterial protein production.Cross-resistance between streptomycin and other aminoglycosides and polypeptides observed.

review image

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Huntington's Disease Research Product Guide

Huntington's Disease Research Product Guide

This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:

  • Somatic Instability
  • Proteolysis and Inclusion Bodies
  • Transcriptional Dysregulation
  • Mitochondrial Dysfunction
  • Nuclear-Cytoplasmic Transport Interference
  • Excitotoxicity
  • Stem Cells