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VX 680

Cat. No. 5907 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5907 has been discontinued.

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说明： High affinity and selective Aurora kinase inhibitor
别名： MK 0457,Tozasertib
化学名： N-[4-[[4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for VX 680

VX 680 is a high affinity and selective Aurora kinase inhibitor (Ki values are 0.6, 5 and 18 nM for Aurora A, Aurora C and Aurora B, respectively). Also exhibits affinity for FLT-3 and Abl. Exhibits selectivity for Aurora kinase over 190 other protein kinases. Inhibits proliferation and induces apoptosis in a number of cancer cell lines in vitro. Reduces tumor size in leukemia and colon cancer cell xenografts in mice.

技术数据 for VX 680

分子量 464.59
公式 C23H28N8OS
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 639089-54-6
PubChem ID 5494449
InChI Key GCIKSSRWRFVXBI-UHFFFAOYSA-N
Smiles CN1CCN(C2=NC(SC3=CC=C(C=C3)NC(C4CC4)=O)=NC(NC5=NNC(C)=C5)=C2)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for VX 680

参考文献是支持产品生物活性的出版物。

Bebbington et al (2009) The discovery of the potent aurora inhibitor MK-0457 (VX-680). Bioorg.Med.Chem.Lett. 19 3586 PMID: 19447622

Harrington et al (2004) VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat.Med. 10 262 PMID: 14981513

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关键词: VX 680, VX 680 supplier, VX680, MK0457, high, affinity, selective, aurora, kinases, inhibitors, inhibits, AurA, AurB, AurC, MK, 0457, Tozasertib, Aurora, Kinases, 5907, Tocris Bioscience

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