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Xanthohumol

Cat. No. 4686 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： p97 ATPase (VCP) inhibitor
化学名： (2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Xanthohumol

Xanthohumol is a p97 ATPase (VCP) inhibitor. Binds to the N domain of p97, impairing autophagosome function and maturation. Inhibits proliferation and induces apoptosis in a variety of human cancer cell lines. Also inhibits DGAT in rat liver microsomes (IC50 = 50.3 μM).

化合物库 for Xanthohumol

Xanthohumol is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Xanthohumol

分子量 354.4
公式 C21H22O5
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 6754-58-1
PubChem ID 639665
InChI Key ORXQGKIUCDPEAJ-YRNVUSSQSA-N
Smiles OC1=C(C(/C=C/C2=CC=C(O)C=C2)=O)C(OC)=CC(O)=C1C/C=C(C)/C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Xanthohumol

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 35.44 100
ethanol 35.44 100

制备储备液 for Xanthohumol

以下数据基于产品分子量 354.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.11 mL 28.22 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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产品说明书 for Xanthohumol

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Xanthohumol

参考文献是支持产品生物活性的出版物。

Sasazawa et al (2012) Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein. ACS Chem.Biol. 7 892 PMID: 22360440

Tabata et al (1997) Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus. Phytochemistry 46 683 PMID: 9366096

Inokoshi et al (2009) Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes. J.Antibiot.(Tokyo) 62 51 PMID: 19132064

If you know of a relevant reference for Xanthohumol, please let us know.

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关键词: Xanthohumol, Xanthohumol supplier, valosin-containing, protein, VCP, transitional, endoplasmic, reticulum, ATPase, TER, inhibitors, autophagosome, autophagy, apoptosis, inhibits, Autophagy, Diacylglycerol, O-Acyltransferase, Other, ER, stress/UPR, p97, 4686, Tocris Bioscience

2 篇 Xanthohumol 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Xanthohumol 的部分引用包括：

den Brok et al (2016) Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation Nature Communications 7 13324 PMID: 27819292

Muthusamy et al (2017) Antiproliferative and apoptotic effects of xanthohumol in cholangiocarcinoma. Oncotarget 8 88069-88078 PMID: 29152142

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