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Submit ReviewXIE62-1004
说明： Inducer of autophagy via interaction of p62 and LC3
化学名： 2-[[[3,4-Bis(phenylmethoxy)phenyl]methyl]amino]ethanol hydrochloride
纯度： ≥98% (HPLC)
生物活性 for XIE62-1004
XIE62-1004 is an inducer of p62-LC3 interaction. Binds to the ZZ domain of p62, leading to p62 self-aggregation and interaction with LC3 on autophagosome membranes; facilitates delivery of cargo proteins to the autophagosome for degradation. Active in vitro and in vivo in a concentration- and time-dependent manner and is specific for wild type p62. Induces degradation of mutant huntingtin in vitro. Can also be used in AUTAC protein degradation systems to induce autophagy through p62 self-aggregation and LC3 interaction.
技术数据 for XIE62-1004
| 分子量 | 399.91 |
| 公式 | C23H25NO3.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2421146-32-7 |
| PubChem ID | 126601715 |
| InChI Key | ROURICFSUKPJOO-UHFFFAOYSA-N |
| Smiles | Cl.OCCNCC1=CC=C(OCC=2C=CC=CC2)C(OCC=3C=CC=CC3)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for XIE62-1004
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 8 | 20 |
制备储备液 for XIE62-1004
以下数据基于产品分子量 399.91。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.5 mL | 62.51 mL | 125.03 mL |
| 1 mM | 2.5 mL | 12.5 mL | 25.01 mL |
| 2 mM | 1.25 mL | 6.25 mL | 12.5 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.5 mL |
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产品说明书 for XIE62-1004
参考文献 for XIE62-1004
参考文献是支持产品生物活性的出版物。
Zhang et al (2018) ZZ-dependent regulation of p62/SQSTM1 in autophagy. Nat.Commun. 9 4373 PMID: 30349045
Cha-Molstad et al (2017) p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis. Nat.Commun. 8 102 PMID: 28740232
If you know of a relevant reference for XIE62-1004, please let us know.
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关键词: XIE62-1004, XIE62-1004 supplier, XIE621004, p62, LC3, p62zz, zz, domain, autophagosome, degrader, degradation, degrade, degrades, mutant, AUTAC, huntingtin, Autophagy, Protein, Dimerizers, 7878, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Autophagy Scientific Review
Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.
Autophagy Poster
Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.