Autophagy Activators
| Cat. No. | Product Name / Activity |
|---|---|
| 3336 | A 769662 |
| Autophagy activator; potent AMPK activator | |
| 1234 | A23187, free acid |
| Causes ER stress; can be used to induce autophagy in mammalian cells | |
| 7680 | ABT 263 |
| Induces autophagy; Bcl-2 family inhibitor | |
| 7699 | AUTAC4 |
| Autophagy-targeting Degrader; targets dysfuntional mitochondria for degradation; ligand of the translocator protein (TSPO) | |
| 1231 | Brefeldin A |
| Causes ER stress; induces autophagy in mammalian cells | |
| 4098 | Carbamazepine |
| Induces autophagy by inhibiting inositol synthesis; Inhibits neuronal NaV channels | |
| 0690 | Clonidine hydrochloride |
| α2 agonist and I1 ligand; thought to enhance autophagy | |
| 1126 | Dexamethasone |
| Anti-inflammatory glucocorticoid; also induces autophagy in ALL cell lines | |
| 3093 | Dorsomorphin dihydrochloride |
| Induces autophagy via an AMPK inhibition-independent mechanism | |
| 7474 | EN6 |
| Activator of autophagy; inactivates mTORC1 signaling | |
| 6188 | Everolimus |
| Autophagy activator; mTOR inhibitor | |
| 0741 | GF 109203X |
| Protein kinase C inhibitor | |
| 0681 | L-690,330 |
| Inositol monophosphatase inhibitor; induces autophagy independently of mTOR inhibition | |
| 6617 | LYN 1604 dihydrochloride |
| Induces autophagy; ULK1 agonist | |
| 2864 | Metformin hydrochloride |
| Activator of LKB1/AMPK; activates autophagy | |
| 1391 | NF 449 |
| Highly selective P2X1 antagonist; Gsα-selective antagonist | |
| 4079 | Niclosamide |
| STAT3 inhibitor; also inhibits mTORC1 signaling. Stimulates autophagy in vitro | |
| 0600 | Nimodipine |
| Induces autophagy; Ca2+ channel blocker (L-type) | |
| 6087 | Perifosine |
| PKB/Akt inhibitor; induces autophagy | |
| 2930 | PI 103 hydrochloride |
| Inhibitor of PI 3-kinase, mTOR and DNA-PK | |
| 1267 | Pifithrin-α hydrobromide |
| p53 inhibitor | |
| 1292 | Rapamycin |
| mTOR inhibitor; induces autophagy | |
| 1418 | Resveratrol |
| Autophagy activator; also cyclooxygenase inhibitor | |
| 0695 | Retinoic acid |
| Autophagy activator; also endogenous retinoic acid receptor agonist | |
| 0790 | Rilmenidine hemifumarate |
| α2 agonist and I1 ligand; thought to enhance autophagy | |
| 1610 | Rottlerin |
| Stimulates autophagy | |
| 4652 | SAHA |
| Autophagy activator; also Class I and II HDAC inhibitor | |
| 4297 | SMER 28 |
| Positive regulator of autophagy | |
| 7558 | SRT 1720 |
| Induces autophagy; SIRT1 activator | |
| 2706 | Temozolomide |
| DNA-methylating antitumor agent; also induces autophagy | |
| 5264 | Temsirolimus |
| Autophagy activator; mTOR inhibitor | |
| 1138 | Thapsigargin |
| Causes ER stress; can be used to induce autophagy in mammalian cells | |
| 4247 | Torin 1 |
| Potent and selective mTOR inhibitor; induces autophagy in HeLa cells | |
| 4248 | Torin 2 |
| Autophagy activator; also potent and selective mTOR inhibitor | |
| 1406 | Trichostatin A |
| Autophagy activator; potent histone deacetylase inhibitor | |
| 3516 | Tunicamycin |
| Causes ER stress; can be used to induce autophagy | |
| 2815 | Valproic acid, sodium salt |
| Reduces inositol levels; induces autophagy | |
| 0654 | Verapamil hydrochloride |
| Ca2+ channel blocker (L-type); induces autophagy | |
| 7878 | XIE62-1004 |
| Inducer of autophagy via interaction of p62 and LC3 |
Autophagy Scientific Review
Our Autophagy review summarizes the molecular mechanisms and physiology of autophagy, as well as the role of autophagy in certain disease states.
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Our Autophagy poster summarizes the molecular machinery, physiology and pathology of autophagy, and highlights chemical compounds that modulate autophagy.
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Our Programmed Cell Death poster gives a summary of the signaling pathways involved in apoptosis, necroptosis and cell survival.
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