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XL 388

Cat. No. 4893 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4893 has been discontinued.

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说明： Potent and selective mTOR inhibitor; antitumor
化学名： [7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-methanone
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (2)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for XL 388

XL 388 is a potent and selective mTOR inhibitor (IC50 = 9.9 nM). Inhibits mTOR activity in an ATP-competitive manner. Exhibits >300-fold selectivity for mTOR over PI 3-K and a range of other kinases. Displays antitumor activity in athymic nude mice implanted with tumor xenografts.

技术数据 for XL 388

分子量 455.5
公式 C23H22FN3O4S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1251156-08-7
PubChem ID 59604787
InChI Key LNFBAYSBVQBKFR-UHFFFAOYSA-N
Smiles NC1=NC=C(C2=CC=C(OCCN(C(C4=CC=C(S(C)(=O)=O)C(F)=C4C)=O)C3)C3=C2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for XL 388

参考文献是支持产品生物活性的出版物。

Takeuchi et al (2013) Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR). J.Med.Chem. 56 2218 PMID: 23394126

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关键词: XL 388, XL 388 supplier, XL388, potent, selective, mtor, inhibitors, inhibits, kinases, antitumor, ATP-competetive, mTOR, 4893, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.

Pathways for XL 388

mTOR Signaling Pathway

mTOR Signaling Pathway

mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.