Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewY 11
说明： Potent and selective FAK inhibitor
化学名： 1-(2-Hydroxyethyl)-3,5,7-triaza-1-azaniatricyclo[3.3.1.13,7]decane bromide
生物活性 for Y 11
Y 11 is a potent inhibitor of focal adhesion kinase (FAK); prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1 μM). Decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines.
技术数据 for Y 11
| 分子量 | 265.15 |
| 公式 | C8H17N4OBr |
| 储存 | Store at -20°C |
| CAS Number | 1086639-59-9 |
| PubChem ID | 24195918 |
| InChI Key | HBPXFHNNLMCUPA-UHFFFAOYSA-M |
| Smiles | OCC[N+]1(CN3C2)CN(C3)CN2C1.[Br-] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Y 11
参考文献 for Y 11
参考文献是支持产品生物活性的出版物。
Golubovskaya et al (2012) A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [3.3.1.13,7]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonoge Carcinogenesis PMID: 22402131
Golubovskaya et al (2008) A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the Y397 site of focal adhesion kinase decreases tumor growth. J.Med.Chem. 51 7405 PMID: 18989950
按产品操作查看相关产品
关键词: Y 11, Y 11 supplier, potent, focal, adhesion, kinase, FAK, inhibits, inhibitors, autophosphorylation, selective, Y11, Focal, Adhesion, Kinase, 4498, Tocris Bioscience
4 篇 Y 11 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Y 11 的部分引用包括：
Gary et al (2019) Trapping, tagging and tracking: Tools for the study of proteins during early development of the sea urchin. Methods Cell Biol 151 283-304 PMID: 30948012
Brown et al (2015) Notch3 overexpression promotes anoikis resistance in epithelial ovarian cancer via upregulation of COL4A2. Mol Cancer Res 13 78 PMID: 25169943
Keasey et al (2018) Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling. J Cell Sci 131 PMID: 29222114
Robinson et al (2015) Segmentation of Image Data from Complex Organotypic 3D Models of Cancer Tissues with Markov Random Fields. PLoS One 10 e0143798 PMID: 26630674
Y 11 的评论
平均评分: 5 (Based on 1 Review.)
Have you used Y 11?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Cell cultures with ECM proteins, integrin blockade and In vitro drug treatments.
By
Anonymous on 03/24/2020
分析类型： In Vitro
种属： Rat
细胞系/组织： rat astroglioma C6 cells
Pharmacological antagonists of FAK for 4 h before RNA or protein isolation FAK antagonists were Y11
