ZIP

Cat. No. 2549 8 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Cell-permeable inhibitor of atypical PKC isozyme PKMζ

别名： z-Pseudosubstrate inhibitory peptide

纯度： ≥95% (HPLC)

说明书

引用文献 (8)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ZIP

ZIP is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC₅₀ = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.

Control Peptide and Biotinylated Peptide also available.

技术数据 for ZIP

分子量	1928.4
公式	C₉₀H₁₅₄N₃₀O₁₇
序列	SIYRRGARRWRKL (Modifications: Ser-1 = Myr-Ser)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	863987-12-6
PubChem ID	16156119
InChI Key	CRKARHQCXWSUMV-HOHDCHNJSA-N
Smiles	[H]N([C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O)C(=O)CCCCCCCCCCCCC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ZIP

溶解性	Soluble to 1 mg/ml in water

产品说明书 for ZIP

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ZIP

参考文献是支持产品生物活性的出版物。

Serrano et al (2005) Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 25 1979 PMID: 15728837

Pastalkova et al (2006) Storage of spatial information by the maintenance mechanism of LTP. Science 313 1141 PMID: 16931766

Ling et al (2002) Protein kinase Mz is necessary and sufficient for LTP maintenance. Nature Neurosci. 5 295

If you know of a relevant reference for ZIP, please let us know.

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关键词: ZIP, ZIP supplier, Cell-permeable, inhibitors, inhibits, atypical, PKC, isozyme, PKMzeta, Protein, Kinases, C, z-Pseudosubstrate, inhibitory, peptide, Kinase, 2549, Tocris Bioscience