主页 / 药理学 / Enzymes / Kinases / AMPK / AMPK Activators / ZLN 024 hydrochloride

ZLN 024 hydrochloride

Cat. No. 5285 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5285 has been discontinued.

View all AMPK products.
说明： Allosteric AMPK activator
化学名： 2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]pyrimidine hydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for ZLN 024 hydrochloride

ZLN 024 hydrochloride is an allosteric AMP-activated protein kinase (AMPK) activator; allosterically stimulates active AMPK heterotrimers, increasing the activity of α1β1γ1 by 1.5-fold and α2β1γ1 by 1.7-fold (EC50 values are 0.42 and 0.95 μM, respectively). Inhibits dephosphorylation of AMPK Thr-172 by PP2Cα. Stimulates glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio. Also decreases fatty acid synthesis and glucose output in primary hepatocytes. Improves glucose tolerance and decreases cholesterol content in db/db mice.

技术数据 for ZLN 024 hydrochloride

分子量 361.69
公式 C13H13BrN2OS.HCl
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1883548-91-1
PubChem ID 91654626
InChI Key MMQCYIMDROWWFE-UHFFFAOYSA-N
Smiles BrC1=C(OCCSC2=NC=CC=N2)C=CC(C)=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for ZLN 024 hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for ZLN 024 hydrochloride

参考文献是支持产品生物活性的出版物。

Li et al (2013) Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice. Toxicol.Appl.Pharmacol. 273 325 PMID: 24055643

Zhang et al (2013) Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One 8 e72092 PMID: 23977216

按标靶查看相关产品

按产品操作查看相关产品

查看全部 AMPK Activators

关键词: ZLN 024 hydrochloride, ZLN 024 hydrochloride supplier, ZLN024, hydrochloride, allosteric, AMPK, activator, diabetes, mellitus, and, metabolic, syndrome, AMP, activated, protein, kinase, glucose, tolerance, Enzyme, Substrates, /, Activators, 5285, Tocris Bioscience

2 篇 ZLN 024 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ZLN 024 hydrochloride 的部分引用包括：

Toby et al (2020) The influence of hypoxia and energy depletion on the response of endothelial cells to the vascular disrupting agent combretastatin A-4-phosphate. Sci Rep 10 9926 PMID: 32555222

Eric et al (2020) Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB. Mol Cell 77 875-886.e7 PMID: 31836389

ZLN 024 hydrochloride 的评论

目前没有该产品的评论。 Be the first to review ZLN 024 hydrochloride and earn rewards!

Have you used ZLN 024 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Pathways for ZLN 024 hydrochloride

AMPK Signaling Pathway

AMPK Signaling Pathway

AMPK signaling pathway plays an important role in the cellular reponse to low levels of available ATP, often caused by stresses such as heat shock, ischemia or hypoxia.