Home / Pharmacology / Enzymes / Kinases / mTOR / mTOR Inhibitors / KU 0063794

KU 0063794

Cat. No. 3725 14 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective mTOR inhibitor
Chemical Name: rel-5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
Purity: ≥97% (HPLC)
Datasheet
Citations (14)
Reviews
Literature (2)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for KU 0063794

KU 0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for mTORC1 and mTORC2). Displays no activity at PI 3-kinase or 76 other kinases tested. Inhibits activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK. Suppresses cell growth and induces G1 cell cycle arrest in vitro.

Technical Data for KU 0063794

M. Wt 465.54
Formula C25H31N5O4
Storage Store at RT
Purity ≥97% (HPLC)
CAS Number 938440-64-3
PubChem ID 16736978
InChI Key RFSMUFRPPYDYRD-CALCHBBNSA-N
Smiles OCC1=C(OC)C=CC(C3=NC2=NC(N5C[C@@H](C)O[C@@H](C)C5)=NC(N4CCOCC4)=C2C=C3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for KU 0063794

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.66 10

Preparing Stock Solutions for KU 0063794

The following data is based on the product molecular weight 465.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.48 mL 107.4 mL 214.8 mL
0.5 mM 4.3 mL 21.48 mL 42.96 mL
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

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Product Datasheets for KU 0063794

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for KU 0063794

References are publications that support the biological activity of the product.

Garcia-Martinez et al (2009) Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochem.J. 421 29 PMID: 19402821

If you know of a relevant reference for KU 0063794, please let us know.

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Keywords: KU 0063794, KU 0063794 supplier, KU0063794, mammalian, target, of, rapamycin, inhibitors, inhibits, selective, mTOR, kinases, suppresses, cell, growth, 3725, Tocris Bioscience

14 Citations for KU 0063794

Citations are publications that use Tocris products. Selected citations for KU 0063794 include:

Hukelmann et al (2016) The cytotoxic T cell proteome and its shaping by the kinase mTOR. J Biol Chem 17 104 PMID: 26551880

López-Cotarelo et al (2015) A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells. Proc Natl Acad Sci U S A 290 827 PMID: 25425646

Munson et al (2015) mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival. Nat Immunol 34 2272 PMID: 26139536

Fei et al (2013) Targeting mTOR to overcome epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small cell lung cancer cells. PLoS One 8 e69104 PMID: 23874880

Sengupta et al (2013) Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals. Free Radic Biol Med 110 18826 PMID: 24191005

Xing et al (2018) The 3-Phosphoinositide-Dependent Protein Kinase 1 Inhibits Rod Photoreceptor Development. Front Cell Dev Biol 6 134 PMID: 30364083

Bodur et al (2018) The IKK-related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists. EMBO J 37 19 PMID: 29150432

Ignacio et al (2020) CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci. Cell Rep 33 108545 PMID: 33357429

Wang et al (2014) SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks. PLoS One 8 e83941 PMID: 24391850

Gandin et al (2016) mTORC1 and CK2 coordinate ternary and eIF4F complex assembly. Nat Commun 7 11127 PMID: 27040916

Ling et al (2016) Insulin promotes proliferation and fibrosing responses in activated pancreatic stellate cells. Am J Physiol Gastrointest Liver Physiol 311 G675-G687 PMID: 27609771

Montané and Menand (2013) ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change. EMBO J 64 4361 PMID: 23963679

Ian E et al (2021) The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt. J Biol Chem 297 100942 PMID: 34245780

Lei et al (2017) SYK kinase mediates brown fat differentiation and activation. Nat Commun 8 2115 PMID: 29235464

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.

Pathways for KU 0063794

mTOR Signaling Pathway

mTOR Signaling Pathway

mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.