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Submit ReviewTrovafloxacin mesylate
Description: Antibiotic; inhibits bacterial DNA synthesis
Alternative Names: CP 99219
Chemical Name: 7-[(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid mesylate
Purity: ≥99% (HPLC)
Biological Activity for Trovafloxacin mesylate
Trovafloxacin mesylate is a fluoroquinolone antibiotic. Inhibits bacterial DNA topoisomerase IV and DNA gyrase and forms a stable quinolone-DNA complex with these enzymes which reversibly inhibits DNA synthesis. Displays potent activity against gram-positive and gram-negative bacteria. Increases the production of mitochondrial NO in immortalized hepatocytes; also increases mitochondrial Ca2+. Inhibits Panx-1 (IC50 ~ 4μM).
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries for Trovafloxacin mesylate
Trovafloxacin mesylate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Trovafloxacin mesylate
| M. Wt | 512.46 |
| Formula | C20H15F3N4O3.CH3SO3H |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 147059-75-4 |
| PubChem ID | 62960 |
| InChI Key | DYNZICQDCVYXFW-GIPYJWDTSA-N |
| Smiles | O=C2C1=CC(F)=C(N4C[C@@]([C@H]5N)([H])[C@@]5([H])C4)N=C1N(C3=C(F)C=C(F)C=C3)C=C2C(O)=O.CS(=O)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Trovafloxacin mesylate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 25.62 | 50 | |
| DMSO | 51.25 | 100 |
Preparing Stock Solutions for Trovafloxacin mesylate
The following data is based on the product molecular weight 512.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.95 mL | 9.76 mL | 19.51 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.9 mL |
| 10 mM | 0.2 mL | 0.98 mL | 1.95 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.39 mL |
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Product Datasheets for Trovafloxacin mesylate
References for Trovafloxacin mesylate
References are publications that support the biological activity of the product.
Neu and Chin (1994) In vitro activity of the new fluoroquinolone CP-99,219. Antimicrob.Agents Chemother. 38 2615 PMID: 7872757
Gootz et al (1996) Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. Antimicrob.Agents Chemother. 40 2691 PMID: 9124824
Poon et al (2014) Unexpected link between an antibiotic, pannexin channels and apoptosis. Nature 507 329 PMID: 24646995
If you know of a relevant reference for Trovafloxacin mesylate, please let us know.
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Citations for Trovafloxacin mesylate
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Reviews for Trovafloxacin mesylate
Average Rating: 5 (Based on 1 Review.)
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Hepatoxic side effects of Trovafloxacin was studied against other several quinolones.
By
Anonymous on 12/15/2019
Species: Human
Hepatoxic side effects of Trovafloxacin was studied against other several quinolones (temafloxacin, sparfloxacin, grepafloxacin, trovafloxacin) which have been withdrawn or their use severely limited soon after their clinical introduction owing to severe and sometimes life-threatening adverse events.
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