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Description: Potent and selective FAK inhibitor
Chemical Name: 1-(2-Hydroxyethyl)-3,5,7-triaza-1-azaniatricyclo[3.3.1.13,7]decane bromide
Biological Activity for Y 11
Y 11 is a potent inhibitor of focal adhesion kinase (FAK); prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1 μM). Decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines.
Technical Data for Y 11
| M. Wt | 265.15 |
| Formula | C8H17N4OBr |
| Storage | Store at -20°C |
| CAS Number | 1086639-59-9 |
| PubChem ID | 24195918 |
| InChI Key | HBPXFHNNLMCUPA-UHFFFAOYSA-M |
| Smiles | OCC[N+]1(CN3C2)CN(C3)CN2C1.[Br-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Y 11
References for Y 11
References are publications that support the biological activity of the product.
Golubovskaya et al (2012) A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [3.3.1.13,7]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonoge Carcinogenesis PMID: 22402131
Golubovskaya et al (2008) A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the Y397 site of focal adhesion kinase decreases tumor growth. J.Med.Chem. 51 7405 PMID: 18989950
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Keywords: Y 11, Y 11 supplier, potent, focal, adhesion, kinase, FAK, inhibits, inhibitors, autophosphorylation, selective, Y11, Focal, Adhesion, Kinase, 4498, Tocris Bioscience
4 Citations for Y 11
Citations are publications that use Tocris products. Selected citations for Y 11 include:
Gary et al (2019) Trapping, tagging and tracking: Tools for the study of proteins during early development of the sea urchin. Methods Cell Biol 151 283-304 PMID: 30948012
Brown et al (2015) Notch3 overexpression promotes anoikis resistance in epithelial ovarian cancer via upregulation of COL4A2. Mol Cancer Res 13 78 PMID: 25169943
Keasey et al (2018) Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling. J Cell Sci 131 PMID: 29222114
Robinson et al (2015) Segmentation of Image Data from Complex Organotypic 3D Models of Cancer Tissues with Markov Random Fields. PLoS One 10 e0143798 PMID: 26630674
Reviews for Y 11
Average Rating: 5 (Based on 1 Review.)
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Cell cultures with ECM proteins, integrin blockade and In vitro drug treatments.
By
Anonymous on 03/24/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: rat astroglioma C6 cells
Pharmacological antagonists of FAK for 4 h before RNA or protein isolation FAK antagonists were Y11
