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Description: DYRK1A/B inhibitor; prodrug of INDY (Cat. No. 4997)
Chemical Name: (1Z)-1-(5-Acetyloxy3-ethyl-2(3H)-benzothiazolylidene)-2-propanone
Purity: ≥98% (HPLC)
Biological Activity for ProINDY
ProINDY is a DYRK1A/B inhibitor; prodrug form of INDY (Cat. No. 4997). Cell permeable. Inhibits phosphorylation of tau protein and rescues repressed calcineurin/NFAT signaling. Recovers Xenopus embryos from head malformation induced by DYRK1A overexpression in vivo.
Technical Data for ProINDY
| M. Wt | 277.34 |
| Formula | C14H15NO3S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 719277-30-2 |
| PubChem ID | 68879595 |
| InChI Key | RLEOCVDWLAYGRX-UHFFFAOYSA-N |
| Smiles | O=C(C)/C=C1SC2=CC=C(OC(C)=O)C=C2N\1CC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ProINDY
References for ProINDY
References are publications that support the biological activity of the product.
Ogawa et al (2010) Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nat.Commun. 1 86 PMID: 20981014
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Keywords: ProINDY, ProINDY supplier, downs, syndrome-related, kinases, Dyrk1A/B, inhibitors, inhibits, tau, phosphorylation, hyperphosphorylation, calcineurin, NFAT, neural, stem, cells, DYRK, 4998, Tocris Bioscience
2 Citations for ProINDY
Citations are publications that use Tocris products. Selected citations for ProINDY include:
Kim et al (2016) A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition. Dis Model Mech 9 839 PMID: 27483355
Seu et al (2015) Stable Phenotypic Changes of the Host T Cells Are Essential to the Long-Term Stability of Latent HIV-1 Infection. Sci Rep 89 6656 PMID: 25878110
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.