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Kobe 0065

Cat. No. 5475 Submit a Review Datasheet / COA / SDS

Discontinued Product

5475 has been discontinued.

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Description: H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling
Chemical Name: N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide
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Biological Activity Technical Data Datasheets References

Biological Activity for Kobe 0065

H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling. Selectively attenuates proliferation and induces apoptosis of cancer cells harboring Ras oncogenes. Reduces growth of K-Ras mutant SW480 colon carcinoma cell xenografts in mice. Orally active.

Technical Data for Kobe 0065

M. Wt 449.79
Formula C15H11ClF3N5O4S
Storage Store at +4°C
CAS Number 436133-68-5
PubChem ID 3827663
InChI Key KSJVAYBCXSURMQ-UHFFFAOYSA-N
Smiles CC1=C(Cl)C=C(NC(NNC2=C([N+]([O-])=O)C=C(C(F)(F)F)C=C2[N+]([O-])=O)=S)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Kobe 0065

References are publications that support the biological activity of the product.

Shima et al (2013) In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc.Natl.Acad.Sci.U.S.A. 110 8182 PMID: 23630290

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Keywords: Kobe 0065, Kobe 0065 supplier, Kobe0065, H-ras-GTP, cRaf, interaction, inhibitors, inhibits, orally, active, Raf, Kinase, 5475, Tocris Bioscience

Citations for Kobe 0065

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