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Submit ReviewRo 3280
Description: Potent and selective PLK1 inhibitor
Chemical Name: 4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide
Purity: ≥98% (HPLC)
Biological Activity for Ro 3280
Ro 3280 is a potent and selective PLK inhibitor (IC50 = 3 nM). Exhibits selectivity for PLK1 over a panel of other kinases. Inhibits growth of a range of tumor cells lines in vitro and induces apoptosis in leukemia cells. Exhibits antitumor activity in mouse colorectal and nasopharyngeal cancer models in vivo.
Technical Data for Ro 3280
| M. Wt | 543.61 |
| Formula | C27H35F2N7O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1062243-51-9 |
| PubChem ID | 25015677 |
| InChI Key | DJNZZLZKAXGMMC-UHFFFAOYSA-N |
| Smiles | COC1=C(C=CC(C(NC2CCN(CC2)C)=O)=C1)NC3=NC=C4N(C(C(F)(CN(C4=N3)C5CCCC5)F)=O)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ro 3280
References for Ro 3280
References are publications that support the biological activity of the product.
Cheung et al (2013) Polo-like kinase inhibitor Ro5203280 has potent antitumor activity in nasopharyngeal carcinoma. Mol.Cancer Ther. 12 1393 PMID: 23686835
Chen et al (2012) Identification of novel, potent and selective inhibitors of Polo-like kinase 1. Bioorg.Med.Chem.Lett. 22 1247 PMID: 22172702
Wang et al (2015) Molecular targeting of the oncoprotein PLK1 in pediatric acute myeloid leukemia: RO3280, a novel PLK1 inhibitor, induces apoptosis in leukemia cells. Int.J.Mol.Sci. 16 1266 PMID: 25574601
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Keywords: Ro 3280, Ro 3280 supplier, Ro3280, Polo-like, kinases, inhibitors, inhibits, apoptosis, inducers, anticancer, PLK1, potent, selective, Kinase, Mitosis, 5968, Tocris Bioscience
Citations for Ro 3280
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Currently there are no citations for Ro 3280.
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.