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Description: PFKFB3 inhibitor
Chemical Name: 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one
Purity: ≥99% (HPLC)
Biological Activity for 3PO
3PO is originally reported to inhibit PFKFB3 (IC50 = 25 μM). More recent reports failed to demonstrate activity in a PFKFB3 kinase assay. Reduces glycolytic flux and suppresses glucose uptake. Inhibits endothelial cell proliferation and causes G2/M cell cycle arrest in vitro. Attenuates vessel sprouting and tumor growth in vivo. Amplifies the antiangiogenic effect of VEGFR blockade.
Technical Data for 3PO
| M. Wt | 210.23 |
| Formula | C13H10N2O |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 13309-08-5 |
| PubChem ID | 5720233 |
| InChI Key | UOWGYMNWMDNSTL-ONEGZZNKSA-N |
| Smiles | O=C(/C=C/C2=CN=CC=C2)C1=CC=NC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 3PO
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.02 | 100 |
Preparing Stock Solutions for 3PO
The following data is based on the product molecular weight 210.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.76 mL | 23.78 mL | 47.57 mL |
| 5 mM | 0.95 mL | 4.76 mL | 9.51 mL |
| 10 mM | 0.48 mL | 2.38 mL | 4.76 mL |
| 50 mM | 0.1 mL | 0.48 mL | 0.95 mL |
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Product Datasheets for 3PO
References for 3PO
References are publications that support the biological activity of the product.
Clem et al (2008) Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol.Cancer Ther. 7 110 PMID: 18202014
Schoors et al (2014) Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. Cell Metab. 19 37 PMID: 24332967
Boyd et al (2015) Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3. J.Med.Chem. 58 3611 PMID: 25849762
If you know of a relevant reference for 3PO, please let us know.
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Keywords: 3PO, 3PO supplier, PFKFB3, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, inhibitors, inhibits, glycolysis, antitumor, antitumour, antiangiogenic, Antiangiogenics, 5121, Tocris Bioscience
Citations for 3PO
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