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A 484954

Cat. No. 4483 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: CaM kinase III (eEF-2 kinase) inhibitor
Chemical Name: 7-Amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for A 484954

A 484954 is an inhibitor of eukaryotic elongation factor-2 (eEF-2) kinase (IC50 = 0.28 μM in enzymatic assay). Reduces eEF-2 phosphorylation with little effect on cancer cell growth.

Technical Data for A 484954

M. Wt 289.29
Formula C13H15N5O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 142557-61-7
PubChem ID 14998470
InChI Key HWODCHXORCTEGU-UHFFFAOYSA-N
Smiles O=C(N(C3CC3)C2=C1C=C(C(N)=O)C(N)=N2)N(CC)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for A 484954

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.89 10

Preparing Stock Solutions for A 484954

The following data is based on the product molecular weight 289.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 34.57 mL 172.84 mL 345.67 mL
0.5 mM 6.91 mL 34.57 mL 69.13 mL
1 mM 3.46 mL 17.28 mL 34.57 mL
5 mM 0.69 mL 3.46 mL 6.91 mL

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References for A 484954

References are publications that support the biological activity of the product.

Chen et al (2011) 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J.Biol.Chem. 286 43951 PMID: 22020937

If you know of a relevant reference for A 484954, please let us know.

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Keywords: A 484954, A 484954 supplier, A484954, eukaryotic, elongation, factor-2, kinase, eef2k, inhibitors, inhibits, CaM, Kinase, 4483, Tocris Bioscience

2 Citations for A 484954

Citations are publications that use Tocris products. Selected citations for A 484954 include:

Pedro R et al (2022) eEF2K Activity Determines Synergy to Cotreatment of Cancer Cells With PI3K and MEK Inhibitors. Mol Cell Proteomics 21 100240 PMID: 35513296

Bouhaddou et al (2020) The Global Phosphorylation Landscape of SARS-CoV-2 Infection Cell 182 685 PMID: 32645325

Do you know of a great paper that uses A 484954 from Tocris? Please let us know.

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