Home / Cell Biology / Regulated Cell Death / Apoptosis / Bcl-2 Family / Bcl-2 Family Inhibitors / ABT 737

ABT 737

Cat. No. 6835 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
Chemical Name: 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ABT 737

ABT 737 is a high affinity Bcl-2 family inhibitor (Ki ≤ 1nM for Bcl-XL, Bcl-2 and Bcl-w). BH3 mimetic; triggers Bax/Bak-mediated apoptosis. Exhibits cytotoxicity in lymphoma cell lines overexpressing bcl-2 (EC50 < 1 μM) and multiple myeloma cells (IC50 = 5-15 μM). Induces apoptosis in patient-derived CLL cells. Promotes regression of SCLC tumors in a mouse xenograft model. Synergizes with certain other anticancer agents.

Technical Data for ABT 737

M. Wt 813.43
Formula C42H45ClN6O5S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 852808-04-9
PubChem ID 11228183
InChI Key HPLNQCPCUACXLM-PGUFJCEWSA-N
Smiles CN(CC[C@@H](NC1=C([N+]([O-])=O)C=C(S(=O)(NC(C2=CC=C(N3CCN(CC3)CC4=C(C5=CC=C(C=C5)Cl)C=CC=C4)C=C2)=O)=O)C=C1)CSC6=CC=CC=C6)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ABT 737

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 81.34 100

Preparing Stock Solutions for ABT 737

The following data is based on the product molecular weight 813.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.23 mL 6.15 mL 12.29 mL
5 mM 0.25 mL 1.23 mL 2.46 mL
10 mM 0.12 mL 0.61 mL 1.23 mL
50 mM 0.02 mL 0.12 mL 0.25 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for ABT 737

References are publications that support the biological activity of the product.

Oltersdorf et al (2005) An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 425 677 PMID: 15902208

van Delft, MF et al (2006) The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell. 10 389 PMID: 17097561

Kline et al (2007) ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells. Leukemia 21 1549 PMID: 17460700

If you know of a relevant reference for ABT 737, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Bcl-2 Family Inhibitors

Keywords: ABT 737, ABT 737 supplier, ABT737, bcl, family, bcl-2, bcl-w, bcl-xl, inhibitors, inhibits, BH3, mimetics, apoptosis, inducers, induces, Bcl-2, Family, 6835, Tocris Bioscience

1 Citation for ABT 737

Citations are publications that use Tocris products. Selected citations for ABT 737 include:

Jerome et al (2022) Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's disease. Cell Metab 34 1248-1263.e6 PMID: 35987203

Do you know of a great paper that uses ABT 737 from Tocris? Please let us know.

Reviews for ABT 737

There are currently no reviews for this product. Be the first to review ABT 737 and earn rewards!

Have you used ABT 737?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for ABT 737

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.