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Submit ReviewAdaphostin
Description: p210bcr/abl kinase inhibitor
Alternative Names: NSC 680410
Chemical Name: 4-[[(2,5-Dihydroxyphenyl)methyl]amino]benzoic acid tricyclo[3.3.1.13,7]dec-1-yl ester
Purity: ≥98% (HPLC)
Biological Activity for Adaphostin
p210bcr/abl tyrosine kinase inhibitor (IC50 = 14 μM). Induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50 values range from 16.8 to 216.3 nM) in vitro. Displays selectivity for chronic myelogenous leukemia (CML) myeloid progenitors in vitro.
Technical Data for Adaphostin
| M. Wt | 393.48 |
| Formula | C24H27NO4 |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 241127-58-2 |
| PubChem ID | 387042 |
| InChI Key | YJZSUCFGHXQWDM-UHFFFAOYSA-N |
| Smiles | O=C(C4=CC=C(NCC5=C(O)C=CC(O)=C5)C=C4)OC12CC(C3)CC(CC3C2)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Adaphostin
References for Adaphostin
References are publications that support the biological activity of the product.
Svingen et al (2000) Effects of the bcl/abl kinase inhibitors AG957 and NSC 680410 on chronic myelogenous leukemia cells in vitro. Clin.Cancer Res. 6 237 PMID: 10656455
Avramis et al (2002) In vitro and in vivo evaluations of the tyrosine kinase inhibitor NSC 680410 against human leukemia and glioblastoma cell lines. Cancer Chemother.Pharmacol. 50 479 PMID: 12451475
Mow et al (2002) Effects of bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro. Blood 99 664 PMID: 11781252
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Keywords: Adaphostin, Adaphostin supplier, p210bcr/abl, kinases, inhibitors, inhibits, chronic, myelogenous, leukaemia, leukemia, CML, NSC680410, NSC, 680410, Abl, Kinase, 3716, Tocris Bioscience
1 Citation for Adaphostin
Citations are publications that use Tocris products. Selected citations for Adaphostin include:
Xia et al (2014) EZH2 silencing with RNA interference induces G2/M arrest in human lung cancer cells in vitro. Biomed Res Int 2014 348728 PMID: 24745014
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