AS 252424

Discontinued Product

3671 has been discontinued.

View all PI 3-kinase products.
Description: Selective inhibitor of PI 3-kinase γ
Chemical Name: 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for AS 252424

AS 252424 is a potent and selective inhibitor of PI 3-kinase γ (IC50 values are 33 and 935 nM for PI 3-Kγ and PI 3-Kα respectively).

Technical Data for AS 252424

M. Wt 305.28
Formula C14H8FNO4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 900515-16-4
PubChem ID 11630874
InChI Key OYYVWNDMOQPMGE-SDQBBNPISA-N
Smiles OC1=CC(F)=CC=C1C2=CC=C(\C=C3/SC(NC3=O)=O)O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for AS 252424

Certificate of Analysis / Product Datasheet
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References for AS 252424

References are publications that support the biological activity of the product.

Condliffe et al (2005) Sequential activation of class IB and IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 106 1432 PMID: 15878979

Pomel et al (2006) Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase γ. J.Med.Chem. 49 3857 PMID: 16789742

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Keywords: AS 252424, AS 252424 supplier, PI3Kgamma, PI3Kγ, PI, 3-kinasegamma, 3-kinaseg, 3-kinaseγ, phosphoinositide, 3, kinases, gamma, γ, signalling, signaling, inositol, lipids, selective, inhibitors, inhibits, AS252424, pi3k, 3-Kinase, 3671, Tocris Bioscience

1 Citation for AS 252424

Citations are publications that use Tocris products. Selected citations for AS 252424 include:

Schepetkin et al (2012) Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol Pharmacol 81 832 PMID: 22434859


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