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Submit ReviewAS 252424 is a potent and selective inhibitor of PI 3-kinase γ (IC50 values are 33 and 935 nM for PI 3-Kγ and PI 3-Kα respectively).
M. Wt | 305.28 |
Formula | C14H8FNO4S |
Storage | Store at +4°C |
Purity | ≥98% (HPLC) |
CAS Number | 900515-16-4 |
PubChem ID | 11630874 |
InChI Key | OYYVWNDMOQPMGE-SDQBBNPISA-N |
Smiles | OC1=CC(F)=CC=C1C2=CC=C(\C=C3/SC(NC3=O)=O)O2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Condliffe et al (2005) Sequential activation of class IB and IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 106 1432 PMID: 15878979
Pomel et al (2006) Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase γ. J.Med.Chem. 49 3857 PMID: 16789742
Keywords: AS 252424, AS 252424 supplier, PI3Kgamma, PI3Kγ, PI, 3-kinasegamma, 3-kinaseg, 3-kinaseγ, phosphoinositide, 3, kinases, gamma, γ, signalling, signaling, inositol, lipids, selective, inhibitors, inhibits, AS252424, pi3k, 3-Kinase, 3671, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for AS 252424 include:
Schepetkin et al (2012) Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol Pharmacol 81 832 PMID: 22434859
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