Home / Pharmacology / Enzymes / Kinases / Raf Kinases / Raf Kinase Inhibitors / AZ 628

AZ 628

Cat. No. 4836 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent Raf kinase inhibitor
Chemical Name: 3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AZ 628

AZ 628 is a potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM for c-Raf1, B-RafV600E and wild-type B-Raf, respectively). Displays selectivity for Raf kinases over a panel of 150 other kinases; inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. Also inhibits growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries for AZ 628

AZ 628 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for AZ 628

M. Wt 451.52
Formula C27H25N5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 878739-06-1
PubChem ID 11676786
InChI Key ZGBGPEDJXCYQPH-UHFFFAOYSA-N
Smiles CC(C)(C#N)C1=CC=CC(C(NC2=CC(NC3=CC(C(N(C)C=N4)=O)=C4C=C3)=C(C)C=C2)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AZ 628

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.15 100

Preparing Stock Solutions for AZ 628

The following data is based on the product molecular weight 451.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.07 mL 22.15 mL
5 mM 0.44 mL 2.21 mL 4.43 mL
10 mM 0.22 mL 1.11 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for AZ 628

References are publications that support the biological activity of the product.

Hatzivassiliou et al (2010) RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 464 431 PMID: 20130576

Montagut et al (2008) Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma. Cancer Res. 68 4853 PMID: 18559533

Khazak et al (2007) Selective Raf inhibition in cancer therapy. Expert Opin.Ther.Targets 11 1587 PMID: 18020980

If you know of a relevant reference for AZ 628, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Raf Kinase Inhibitors

Keywords: AZ 628, AZ 628 supplier, AZ628, AZ_628, potent, Raf, kinases, inhibitors, inhibits, B-Raf, c-Raf, Kinase, 4836, Tocris Bioscience

2 Citations for AZ 628

Citations are publications that use Tocris products. Selected citations for AZ 628 include:

Echeverría et al (2019) The sensitivity to Hsp90 inhibitors of both normal and oncogenically transformed cells is determined by the equilibrium between cellular quiescence and activity. PLoS One 14 e0208287 PMID: 30726209

Sahu et al (2016) Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs. Nat Commun 7 12351 PMID: 27484502

Do you know of a great paper that uses AZ 628 from Tocris? Please let us know.

Reviews for AZ 628

There are currently no reviews for this product. Be the first to review AZ 628 and earn rewards!

Have you used AZ 628?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review