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Submit ReviewAZ PFKFB3 26
Description: Potent and selective PFKFB3 inhibitor
Chemical Name: (2S)-N-[4-[[3-Cyano-1-(2-methylpropyl)-1H-indol-5-yl]oxy]phenyl]-2-pyrrolidinecarboxamide
Purity: ≥98% (HPLC)
Biological Activity for AZ PFKFB3 26
AZ PFKFB3 26 is a potent and selective PFKFB3 inhibitor (IC50 = 0.023 μM). Selective for PFKFB3 over PFKFB2 and PFKFB1 isoforms (IC50 values are 0.382 μM and 2.06 μM, respectively). Reduces levels of fructose-1,6-bisphosphate in A549 cells (IC50 = 0.343 μM). Exhibits no significant inhibition of other kinases.
Compound Libraries for AZ PFKFB3 26
AZ PFKFB3 26 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for AZ PFKFB3 26
| M. Wt | 402.49 |
| Formula | C24H26N4O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1704740-52-2 |
| PubChem ID | 118735769 |
| InChI Key | OOGHGWKBJXQNEJ-QFIPXVFZSA-N |
| Smiles | N#CC1=CN(CC(C)C)C2=C1C=C(OC3=CC=C(NC([C@H]4NCCC4)=O)C=C3)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AZ PFKFB3 26
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.25 | 100 | |
| ethanol | 40.25 | 100 |
Preparing Stock Solutions for AZ PFKFB3 26
The following data is based on the product molecular weight 402.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.48 mL | 12.42 mL | 24.85 mL |
| 5 mM | 0.5 mL | 2.48 mL | 4.97 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.48 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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Product Datasheets for AZ PFKFB3 26
References for AZ PFKFB3 26
References are publications that support the biological activity of the product.
Boyd et al (2015) Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3. J.Med.Chem. 58 3611 PMID: 25849762
If you know of a relevant reference for AZ PFKFB3 26, please let us know.
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Keywords: AZ PFKFB3 26, AZ PFKFB3 26 supplier, AZPFKFB326, phosphofructokinase2, PFKFB3, inhibitors, inhibits, fructose-1,6-bisphosphate, kinase, cancer, 5675, Tocris Bioscience
Citations for AZ PFKFB3 26
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Literature in this Area
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Cancer Metabolism Research Product Guide
This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:
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