Home / Pharmacology / Enzymes / Kinases / mTOR / mTOR Inhibitors / AZD 8055

AZD 8055

Cat. No. 7840 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Highly potent and selective mTOR inhibitor
Chemical Name: 5-[2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AZD 8055

AZD 8055 is a highly potent, selective and ATP-competitive mTOR inhibitor (IC50 = 0.8 nM). Inhibits growth and induces autophagy in a range of cancer cell lines and xenografts, including NSCLC and glioblastoma (IC50 values are 20, 50 and 53 nM in H838, A549 and U87MG cell lines, respectively). Orally bioavailable.

Technical Data for AZD 8055

M. Wt 465.55
Formula C25H31N5O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1009298-09-2
PubChem ID 25262965
InChI Key KVLFRAWTRWDEDF-IRXDYDNUSA-N
Smiles C[C@@H]1N(CCOC1)C2=NC(N3[C@H](COCC3)C)=NC4=C2C=CC(C5=CC(CO)=C(C=C5)OC)=N4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AZD 8055

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.55 100
ethanol 9.31 20

Preparing Stock Solutions for AZD 8055

The following data is based on the product molecular weight 465.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL
10 mM 0.21 mL 1.07 mL 2.15 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for AZD 8055

References are publications that support the biological activity of the product.

Chresta et al (2010) AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity. Cancer Res. 70 288 PMID: 20028854

If you know of a relevant reference for AZD 8055, please let us know.

View Related Products by Target

View Related Products by Product Action

View all mTOR Inhibitors

Keywords: AZD 8055, AZD 8055 supplier, AZD8055, highly, potent, selective, ATP-competitive, mtor, inhibitor, inhibitors, autophagy, cancer, mTOR, 7840, Tocris Bioscience

Citations for AZD 8055

Citations are publications that use Tocris products.

Currently there are no citations for AZD 8055. Do you know of a great paper that uses AZD 8055 from Tocris? Please let us know.

Reviews for AZD 8055

There are currently no reviews for this product. Be the first to review AZD 8055 and earn rewards!

Have you used AZD 8055?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.

Pathways for AZD 8055

mTOR Signaling Pathway

mTOR Signaling Pathway

mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.