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AZM 475271

Cat. No. 3963 4 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Src tyrosine kinase inhibitor
Chemical Name: N-(2-Chloro-5-methoxyphenyl)-6-methoxy
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AZM 475271

AZM 475271 is a src tyrosine kinase inhibitor. Reduces tumor size, vascularity and metastasis, and increases apoptosis in human pancreatic cells grown in nude mice. Also exhibits antiangiogenic activity in vitro and in vivo. Sensitizes tumor cells to the cytotoxic effects of gemcitabine (Cat. No. 3259).

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries for AZM 475271

AZM 475271 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for AZM 475271

M. Wt 442.94
Formula C23H27ClN4O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 476159-98-5
PubChem ID 5330175
InChI Key WPOXAFXHRJYEIC-UHFFFAOYSA-N
Smiles ClC1=CC=C(OC)C=C1NC3=NC=NC2=CC(OCC4CCN(C)CC4)=C(OC)C=C23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AZM 475271

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.29 100

Preparing Stock Solutions for AZM 475271

The following data is based on the product molecular weight 442.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.29 mL 22.58 mL
5 mM 0.45 mL 2.26 mL 4.52 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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References for AZM 475271

References are publications that support the biological activity of the product.

Yezhelyev et al (2004) Inhibition of Src tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice. Clin.Cancer Res. 10 8028 PMID: 15585638

Summy et al (2005) AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes. Mol.Cancer Ther. 4 1900 PMID: 16373705

If you know of a relevant reference for AZM 475271, please let us know.

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Keywords: AZM 475271, AZM 475271 supplier, AZM475271, inhibits, Src, family, tyrosine, kinase, inhibitors, astrazeneca, Kinases, 3963, Tocris Bioscience

4 Citations for AZM 475271

Citations are publications that use Tocris products. Selected citations for AZM 475271 include:

Thakur et al (2015) Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer. Sci Rep 5 10194 PMID: 25973915

Gautam et al (2016) Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling. Mol Cancer 15 75 PMID: 27871326

Wang et al (2016) Smooth muscle contraction and growth of stromal cells in the human prostate are both inhibited by the Src family kinase inhibitors, AZM475271 and PP2. Br J Pharmacol 173 3342 PMID: 27638545

Leoni et al (2013) Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest 123 443 PMID: 23241962

Do you know of a great paper that uses AZM 475271 from Tocris? Please let us know.

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