Bryostatin 1

Name: Bryostatin 1
Brand: Tocris Bioscience
SKU: 2383
Rating: 4 (1 reviews)

Cat. No. 2383 6 Citations 1 Review Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Description: Protein kinase C activator

Alternative Names: NSC 339555

Chemical Name: (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1^3,7.1^11,15]nonacos-8-en-12-yl-(2E, 4E)-2,4-octadienoic acid ester

Purity: ≥98% (HPLC)

Datasheet

Citations (6)

Reviews (1)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Bryostatin 1

Bryostatin 1 is a protein kinase C (PKC) activator that binds with high affinity (K_i = 1.35 nM). Initially activates and subsequently induces downregulation of PKC isozymes. Sensitizes tumor cells to cytotoxic effects of anticancer agents. Restores hippocampal synapses and spatial learning and memory in an in vivo model of fragile X syndrome.

Technical Data for Bryostatin 1

M. Wt	905.04
Formula	C₄₇H₆₈O₁₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	83314-01-6
PubChem ID	5280757
InChI Key	MJQUEDHRCUIRLF-TVIXENOKSA-N
Smiles	O=C(C)O[C@H](C(C)2C)C[C@@H](C[C@@H](O)CC(O[C@@H]([C@H](O)C)C[C@@H](O4)C3)=O)O[C@@]2(O)C[C@H](C1)O[C@@H](/C=C/C(C)(C)[C@@]4(O)[C@@H](OC(/C=C/C=C/CCC)=O)/C3=C/C(OC)=O)C/C1=C\C(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Bryostatin 1

Solubility

Soluble in DMSO and in ethanol

Product Datasheets for Bryostatin 1

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for Bryostatin 1

References are publications that support the biological activity of the product.

Lorenzo et al (1997) The catalytic domain of protein kinase Cδ confers protection from down-regulation induced by bryostatin 1. J.Biol.Chem. 272 33338 PMID: 9407126

Sun and Alkon (2006) Bryostatin-1: pharmacology and therapeutic potential as a CNS drug. CNS Drug Rev. 12 1 PMID: 16834754

Wender et al (1998) The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1. Proc.Natl.Acad.Sci.USA 95 6624 PMID: 9618462

Sun et al (2014) Bryostatin-1 restores hippocampal synapses and spatial learning and memory in adult fragile X mice. J Pharmacol Exp Ther. 349 393 PMID: 24659806

If you know of a relevant reference for Bryostatin 1, please let us know.

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Keywords: Bryostatin 1, Bryostatin 1 supplier, Protein, kinases, C, activators, PKC, Bryostatin1, NSC339555, NSC, 339555, Kinase, 2383, Tocris Bioscience