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Submit ReviewBryostatin 3
Description: Potent protein kinase C activator
Chemical Name: (4S,5S,7E,9R,11Z,13S,15S,17S,19R,21R,25R,27R,27aS)-17-(Acetyloxy)-4,5,6,9,10,11,12,13,14,15,16,17,18,19, 20,21,22,23,25,26,27,27a-docosahydro-5,15,21-trihydroxy-25-[(1R)-1-hydroxyethyl]-11-(2-methoxy-2-oxoethylidene)-6,6,16,16-tetramethyl-2,23-dioxo-5,27:9,13:15,19-triepoxy-2H-furo[2,3-e]oxacyclohexacosin-4-yl-(2E,4E)-2,4-octadienoic acid ester
Purity: ≥95% (HPLC)
Biological Activity for Bryostatin 3
Bryostatin 3 is a potent protein kinase C activator (KI = 2.75 nM). Attenuates phorbol 12-myristate 13-acetate (Cat. No. 1201) inhibition of GH4C1 pituitary cell proliferation in vitro.
Technical Data for Bryostatin 3
| M. Wt | 888.99 |
| Formula | C46H64O17 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 143370-84-7 |
| PubChem ID | 10395929 |
| InChI Key | BSNHYLUEHJOXFN-HBUIWOJHSA-N |
| Smiles | O=C(O[C@@H]([C@@H](C)O)C[C@@H](O5)[C@H]3O4)C[C@H](O)C[C@H](C[C@H](OC(C)=O)C(C)2C)O[C@@]2(O)C[C@H](C1)O[C@@H](/C=C/C(C)(C)[C@@]5(O)[C@@H](OC(/C=C/C=C/CCC)=O)C3=CC4=O)C/C1=C\C(OC)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Bryostatin 3
References for Bryostatin 3
References are publications that support the biological activity of the product.
Mackanos et al (1991) BryoSTAT selectively regulate protein kinase C-mediated effects on GH4 cell proliferation. J.Biol.Chem. 266 1120 PMID: 1904062
Wender et al (1988) Modeling of the bryoSTAT to the phorbol ester pharmacophore on protein kinase C. Proc.Natl.Acad.Sci.U.S.A. 85 7197 PMID: 3174627
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Keywords: Bryostatin 3, Bryostatin 3 supplier, potent, protein, kinases, c, activator, Bryostatin, 3, natural, Protein, Kinase, C, 5238, Tocris Bioscience
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