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Submit ReviewCCT 137690
Description: Potent pan-Aurora kinase inhibitor
Chemical Name: 6-Bromo-7-[4-[(5-methyl-3-isoxazolyl)methyl]-1-piperazinyl]-2-[4-(4-methyl-1-piperazinyl)phenyl]-3H-imidazo[4,5-b]pyridine
Purity: ≥98% (HPLC)
Biological Activity for CCT 137690
CCT 137690 is a potent inhibitor of Aurora kinases (IC50 values are 0.015, 0.019 and 0.025 μM at Aurora A, Aurora C and Aurora B respectively). Displays antiproliferative activity in a range of human tumor cell lines. Orally bioavailable.
Technical Data for CCT 137690
| M. Wt | 551.48 |
| Formula | C26H31BrN8O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1095382-05-0 |
| PubChem ID | 25154041 |
| InChI Key | GFLQCBTXTRCREJ-UHFFFAOYSA-N |
| Smiles | CN(CC4)CCN4C(C=C3)=CC=C3C2=NC1=C(N5CCN(CC6=NOC(C)=C6)CC5)C(Br)=CN=C1N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CCT 137690
References for CCT 137690
References are publications that support the biological activity of the product.
Bavetsias et al (2010) Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate. J.Med.Chem. 53 5213 PMID: 20565112
Faisal et al (2011) The Aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo. Mol.Cancer Ther. 10 2115 PMID: 21885865
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Keywords: CCT 137690, CCT 137690 supplier, CCT137690, aurora, kinases, pan-aurora, inhibitors, inhibits, antiproliferative, Aurora, Kinases, 4291, Tocris Bioscience
Citations for CCT 137690
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Currently there are no citations for CCT 137690.
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Cell Cycle and DNA Damage Research Product Guide
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In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.