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CEP

Cat. No. 8108 Submit a Review Datasheet / COA / SDS
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Description: Chemoproteomic reagent, clickable electrophilic purine for RNA binding profiling in live cells
Chemical Name: 2,6-Dichloro-7-(2-propyn-1-yl)-7H-purine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CEP

CEP is a chemoproteomic reagent. It is a clickable electrophilic purine used to directly quantify protein-RNA interactions on proteins through photoaffinity competition with 4-thiouridine (4SU)-labeled RNA in cells. It is a cysteine reactive probe used in photo-activatable-competition and chemoproteomic enrichment (PACCE) method for global quantification of protein-RNA interactions in living cells.

Technical Data for CEP

M. Wt 227.05
Formula C8H4Cl2N4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1838570-66-3
PubChem ID 155590179
InChI Key DQZMJDUCMIRFBJ-UHFFFAOYSA-N
Smiles ClC1=NC(N=CN2CC#C)=C2C(Cl)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CEP

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.7 100
ethanol 2.27 10 with gentle warming

Preparing Stock Solutions for CEP

The following data is based on the product molecular weight 227.05. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.4 mL 22.02 mL 44.04 mL
5 mM 0.88 mL 4.4 mL 8.81 mL
10 mM 0.44 mL 2.2 mL 4.4 mL
50 mM 0.09 mL 0.44 mL 0.88 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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References for CEP

References are publications that support the biological activity of the product.

Heindel et al (2023) Chemoproteomic capture of RNA binding activity in living cells. Nat.Commun. 14 6282 PMID: 37805600

If you know of a relevant reference for CEP, please let us know.

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Keywords: CEP, CEP supplier, Chemoproteomic, reagent, clickable, electrophilic, purine, RNA, protein, binding, profiling, PACCE, photoactivatable, competition, and, chemoproteomic, enrichment, DNA,, Protein, Synthesis, Biochemicals, Molecular, Biology, 8108, Tocris Bioscience

Citations for CEP

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