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Submit ReviewCercosporamide
Description: Potent Mnk2 inhibitor
Chemical Name: (9aS)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancaboxamide
Purity: ≥96% (HPLC)
Biological Activity for Cercosporamide
Cercosporamide is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC50 values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). Blocks eIF4E phosphorylation; exhibits antiproliferative and proapoptotic activity in cancer cells in vitro. Also inhibits Pkc1. Orally bioavailable.
Technical Data for Cercosporamide
| M. Wt | 331.28 |
| Formula | C16H13NO7 |
| Storage | Store at -20°C |
| Purity | ≥96% (HPLC) |
| CAS Number | 131436-22-1 |
| PubChem ID | 131379 |
| InChI Key | GEWLYFZWVLXQME-MRXNPFEDSA-N |
| Smiles | OC1=CC(O)=C(C(N)=O)C3=C1[C@@]2(C)C(O3)=CC(O)=C(C(C)=O)C2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Cercosporamide
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.31 | 10 |
Preparing Stock Solutions for Cercosporamide
The following data is based on the product molecular weight 331.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.19 mL | 150.93 mL | 301.86 mL |
| 0.5 mM | 6.04 mL | 30.19 mL | 60.37 mL |
| 1 mM | 3.02 mL | 15.09 mL | 30.19 mL |
| 5 mM | 0.6 mL | 3.02 mL | 6.04 mL |
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Product Datasheets for Cercosporamide
References for Cercosporamide
References are publications that support the biological activity of the product.
Konicek et al (2011) Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases. Cancer Res. 71 1849 PMID: 21233335
Hou et al (2012) Targeting Mnks for cancer therapy. Oncotarget 3 118 PMID: 22392765
Sussman et al (2004) Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening. Eukaryot.Cell 3 932 PMID: 15302826
If you know of a relevant reference for Cercosporamide, please let us know.
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Keywords: Cercosporamide, Cercosporamide supplier, antifungals, Mnk2, MKNK2, MAP-kinase, interacting, kinases, Jak3, inhibitors, inhibits, JAK, Kinase, Mnk, 4500, Tocris Bioscience
1 Citation for Cercosporamide
Citations are publications that use Tocris products. Selected citations for Cercosporamide include:
Westergard et al (2019) Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress. EMBO Mol Med 11 PMID: 30617154
Do you know of a great paper that uses Cercosporamide from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.