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Submit ReviewCHIR 98014
Description: Highly potent and selective GSK-3 inhibitor
Chemical Name: N6-[2-[[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-pyridinediamine
Purity: ≥98% (HPLC)
Biological Activity for CHIR 98014
CHIR 98014 is a highly potent and selective GSK-3 inhibitor (IC50 values are 0.58 and 0.65 nM for the β and α isoforms, respectively). Exhibits >500-fold selectivity for GSK-3β over a range of other kinases. Improves insulin sensitivity of muscle strips from diabetic rats in vitro and decreases insulin and glucose levels in the oral glucose tolerance test in vivo. Activates Wnt signaling in human adipose stem cells (hASC) and promotes the production of definitive endoderm. Has been used in protocols to derive epicardial cells from hPSCs.
Technical Data for CHIR 98014
| M. Wt | 486.31 |
| Formula | C20H17Cl2N9O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 252935-94-7 |
| PubChem ID | 53396311 |
| InChI Key | MDZCSIDIPDZWKL-UHFFFAOYSA-N |
| Smiles | NC1=NC(NCCNC2=NC=C(C(C3=C(C=C(C=C3)Cl)Cl)=N2)N4C=CN=C4)=CC=C1[N+]([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CHIR 98014
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.73 | 20 with gentle warming |
Preparing Stock Solutions for CHIR 98014
The following data is based on the product molecular weight 486.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 10.28 mL | 51.41 mL | 102.82 mL |
| 1 mM | 2.06 mL | 10.28 mL | 20.56 mL |
| 2 mM | 1.03 mL | 5.14 mL | 10.28 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.06 mL |
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Product Datasheets for CHIR 98014
References for CHIR 98014
References are publications that support the biological activity of the product.
Ring et al (2003) Selective glycogen synthase kinase 3 inhibitors potentiate Ins activation of glucose transport and utilization in vitro and in vivo. Diabetes 52 588 PMID: 12606497
Paik and Wu et al (2017) Simply derived epicardial cells. Nat.Biomed.Eng. 1 PMID: 29354320
Huang et al (2017) Activation of Wnt/β-catenin signalling via GSK3 inhibitors direct differentiation of human adipose stem cells into functional hepatocytes. Sci.Rep. 7 40716 PMID: 28094799
If you know of a relevant reference for CHIR 98014, please let us know.
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Citations for CHIR 98014
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