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Submit ReviewCompound 401
Description: Selective DNA-PK and mTOR inhibitor
Chemical Name: 2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one
Purity: ≥99% (HPLC)
Biological Activity for Compound 401
Compound 401 is a reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) (IC50 values are 0.28 and 5.3 μM respectively). Displays little affinity for other commonly studied kinases including PI 3-K, ATM and ATR (IC50 values are all > 100 μM). Induces apoptosis in vitro.
Technical Data for Compound 401
| M. Wt | 281.31 |
| Formula | C16H15N3O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 168425-64-7 |
| PubChem ID | 10039361 |
| InChI Key | BVRDQVRQVGRNHG-UHFFFAOYSA-N |
| Smiles | O=C3N2C=CC1=CC=CC=C1C2=NC(N4CCOCC4)=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Compound 401
References for Compound 401
References are publications that support the biological activity of the product.
Griffen et al (2005) Selective benzopyranone and pyrimido[2,1-α]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies and radiosensitization of a human tumor cell line in vitro. J.Med.Chem. 48 569 PMID: 15658870
Ballo et al (2007) Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)oyrimido[2,1-α]isoquinolin-4-one. J.Biol.Chem. 282 24463 PMID: 17562705
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Keywords: Compound 401, Compound 401 supplier, Selective, DNA-PK, mTOR, inhibitors, inhibits, Checkpoint, Control, Kinases, DNA-Dependent, Protein, Kinase, PI3K, Phosphoinositide, PI, 3-kinase, Akt, Signaling, Signalling, Mammalian, Target, Rapamycin, FRAP, Compound401, DNA-dependent, 3271, Tocris Bioscience
Citations for Compound 401
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Cell Cycle and DNA Damage Research Product Guide
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