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Submit ReviewCryptotanshinone
Description: STAT3 inhibitor. Also displays multiple other activities
Chemical Name: 1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl[1,2-b]furan-10,11-dione
Purity: ≥98% (HPLC)
Biological Activity for Cryptotanshinone
Major tanshinone isolated from Salvia miltiorrhiza that exhibits multiple activities. Exhibits antitumor activity via inhibition STAT3 activity (IC50 = 4.6 μM). Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also improves cognitive impairment in Alzheimer's disease transgenic mice by inhibition of acetylcholinesterase (IC50 = 4.09 μM) and reduction in Aβ peptide generation.
Technical Data for Cryptotanshinone
| M. Wt | 296.36 |
| Formula | C19H20O3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 35825-57-1 |
| PubChem ID | 160254 |
| InChI Key | GVKKJJOMQCNPGB-JTQLQIEISA-N |
| Smiles | O=C(C1=C(C4=C3[C@@H](C)CO4)C=CC2=C1CCCC(C)2C)C3=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Cryptotanshinone
References for Cryptotanshinone
References are publications that support the biological activity of the product.
Kim et al (2007) Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase. Mol.Pharmacol. 72 62 PMID: 17429005
Shin et al (2009) Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res. 69 193 PMID: 19118003
Zhang et al (2009) Cryptotanshinone, a compound from Saliva miltiorrhiza modulates amyloid precursor protein metabolism and attenuates β-amyloid deposition through upregulating α-secretase in vivo and in vitro. Neurosci.Letts. 452 90
Wong et al (2009) Cryptotanshinone, an acetylcholinesterase inhibitor from Salivia miltiorrhiza, ameliorates scopolamine-induced amnesia in morris water maze task. Planta Med. 76 288
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Keywords: Cryptotanshinone, Cryptotanshinone supplier, acetylcholinesterases, inhibitors, inhibits, Abeta, amyloid-beta, beta-amyloid, b-amyloid, AMP-activated, protein, kinases, AMPK, STAT3, signal, transducers, activators, transcription, factors, β-amyloid, amyloidb, amyloidβ, STAT, Amyloid, Beta, Peptides, Cholinesterases, 3713, Tocris Bioscience
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Pathways for Cryptotanshinone
