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Submit ReviewCTA 056
Description: ITK inhibitor
Chemical Name: 1,5-Dihydro-7-(phenylmethyl)-1-[3-(1-piperidinyl)propyl]-2-[4-(4-pyridinyl)phenyl]-6H-imidazo[4,5-g]quinoxalin-6-one
Purity: ≥98% (HPLC)
Biological Activity for CTA 056
CTA 056 is an interleukin-2-inducible T-cell kinase (ITK) inhibitor (IC50 values are 0.1, 0.4 and 5 μM for ITK, BTK and ETK, respectively). Inhibits growth of cancer cells expressing ITK, including MOLT-4 and Jurkat cells in vitro. Induces apoptosis in Jurkat cells. Inhibits MOLT-4 xenograft tumor growth in mice.
Technical Data for CTA 056
| M. Wt | 554.68 |
| Formula | C35H34N6O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1265822-30-7 |
| PubChem ID | 49870925 |
| InChI Key | BSSBAJKNZOHHCA-UHFFFAOYSA-N |
| Smiles | O=C2C(CC7=CC=CC=C7)=NC1=CC3=C(N=C(C5=CC=C(C6=CC=NC=C6)C=C5)N3CCCN4CCCCC4)C=C1N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CTA 056
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.55 | 10 with gentle warming |
Preparing Stock Solutions for CTA 056
The following data is based on the product molecular weight 554.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.03 mL | 90.14 mL | 180.28 mL |
| 0.5 mM | 3.61 mL | 18.03 mL | 36.06 mL |
| 1 mM | 1.8 mL | 9.01 mL | 18.03 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.61 mL |
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Product Datasheets for CTA 056
References for CTA 056
References are publications that support the biological activity of the product.
Guo et al (2012) Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs. Mol.Pharmacol. 82 938 PMID: 22899868
If you know of a relevant reference for CTA 056, please let us know.
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Keywords: CTA 056, CTA 056 supplier, CTA056, cancer, apoptosis, interleukin, 2, inducible, T-cell, kinase, Itk, inhibitors, inhibits, induces, inducers, ITK, 4726, Tocris Bioscience
1 Citation for CTA 056
Citations are publications that use Tocris products. Selected citations for CTA 056 include:
Mues et al (2019) High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions. Cell Rep 27 631 PMID: 30970263
Do you know of a great paper that uses CTA 056 from Tocris? Please let us know.
Reviews for CTA 056
Average Rating: 5 (Based on 1 Review.)
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T-ALL Network and Pharmacological Validation of Synthetic Lethal Screen.
By
Anonymous on 03/26/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: T cell line
10uM
