Home / Product Type / Reagents / Viral Transduction Enhancers / Cyclosporin H

Cyclosporin H

Cat. No. 6982 Submit a Review Datasheet / COA / SDS
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Description: Enhances lentiviral transduction
Chemical Name: 5-(N-Methyl-D-valine)cyclosporin A
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Cyclosporin H

Cyclosporin H is a viral transduction enhancer. Increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Displays an additive effect when combined with rapamycin (Cat. No. 1292) or prostaglandin E2 (Cat. No. 2296). Lacks immunosuppressant activity of cyclosporin A (Cat. No. 1101).

Technical Data for Cyclosporin H

M. Wt 1202.64
Formula C62H111N11O12
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 83602-39-5
PubChem ID 6476564
InChI Key PMATZTZNYRCHOR-JLPRAAIDSA-N
Smiles [H][C@]1(NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC(=O)[C@]([H])([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@@]([H])(C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@]([H])(CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C1=O)C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Cyclosporin H

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 120.26 100
ethanol 60.13 50

Preparing Stock Solutions for Cyclosporin H

The following data is based on the product molecular weight 1202.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.83 mL 4.16 mL 8.32 mL
5 mM 0.17 mL 0.83 mL 1.66 mL
10 mM 0.08 mL 0.42 mL 0.83 mL
50 mM 0.02 mL 0.08 mL 0.17 mL

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Product Datasheets for Cyclosporin H

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Cyclosporin H

References are publications that support the biological activity of the product.

Petrillo et al (2018) Cyclosporine H overcomes innate immune restrictions to improve lentiviral transduction and gene editing in human hematopoietic stem cells. Cell Stem Cell. 23 820 PMID: 30416070

If you know of a relevant reference for Cyclosporin H, please let us know.

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Citations for Cyclosporin H

Citations are publications that use Tocris products.

Currently there are no citations for Cyclosporin H. Do you know of a great paper that uses Cyclosporin H from Tocris? Please let us know.

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Literature in this Area

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Stem Cell Research Product Guide

Stem Cell Research Product Guide

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