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FX 1

Cat. No. 6323 Submit a Review Datasheet / COA / SDS

Discontinued Product

6323 has been discontinued.

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Description: Bcl-6 inhibitor; 10-fold more potent than endogenous Bcl-6 corepressors
Chemical Name: (5Z)-5-(5-Chloro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4-oxo-2-thioxo-3-thiazolidinepropanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for FX 1

FX 1 is a Bcl-6 inhibitor (Kd = 3 μM); exhibits 10-fold greater potency than endogenous Bcl-6 corepressors. Disrupts formation of Bcl-6 repression complex. Induces regression of established tumors in mice bearing DLBCL xenograft.

Technical Data for FX 1

M. Wt 368.82
Formula C14H9ClN2O4S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1426138-42-2
PubChem ID 66488970
InChI Key VISHSGZPGQKEFX-KHPPLWFESA-N
Smiles OC(CCN1C(S/C(C1=O)=C2C(NC3=CC=C(C=C\23)Cl)=O)=S)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for FX 1

References are publications that support the biological activity of the product.

Cardenas et al (2016) Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma. J.Clin.Invest. 126 3351 PMID: 27482887

Cardenas et al (2017) The expanding role of the BCL6 oncoprotein as a cancer therapeutic target. Clin.Cancer Res. 23 885 PMID: 27881582

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Citations for FX 1

Citations are publications that use Tocris products.

Currently there are no citations for FX 1.

Reviews for FX 1

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for FX 1

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.